Probenecid Nalidixic acid

Drugs that may interact with nalidixic acid include theophylline, caffeine, oral anticoagulants, bacteriostatic agents, probenecid, antacids (containing magnesium, aluminum, and calcium), sucralfate, iron salts, multivitamins containing zinc, didanosine, antiarrhythmic agents, and melphalan. [Pg.1552]

Nalidixic Acid Nalidixic acid should not be given with nitrofurantoin or mel-phalan. It interacts with cyclosporin, probenecid, and warfarin. [Pg.335]

PROBENECID QUINOLONES -CIPROFLOXACIN, LEVOFLOXACIN, NALIDIXIC ACID, NORFLOXACIN t ciprofloxacin, nalidixic acid and norfloxacin levels Uncertain Watch for t incidence of side-effects. Moxifloxacin, ofloxacin and sparfloxacin do not seem to interact and could be used as alternative therapy... [Pg.485]

Glucose 6-phosphate dehydrogenase deficiency (G-6-PD) Aspirin, BAL (dimercaprol), chloroquine, chloramphenicol, dapsone hydroxychloroquine, nalidixic acid, nitrofurantoin, primaquine, probenecid, quinine, quinidine, sulfonamides Hemolytic anemia... [Pg.51]

Probenecid increases the serum concentrations of cinox-acin (145), enoxacin (146), and nalidixic acid (147) probably by inhibiting their renal tubular secretion. [Pg.1403]

Vree TB, Van den Biggelaar-Martea M, Van Ewijk-Beneken Kolmer EW, Hekster Y A. Probenecid inhibits the renal clearance and renal glucmonidation of nalidixic acid. A pilot experiment. Pharm World Sci 1993 15(4) 165-70. [Pg.1407]

Probenecid increases the serum ieveis and/or decreases the urinary excretion of cinoxacin, ciprofloxacin, clinafloxacin, enoxacin, fleroxacin, levofloxacin, nalidixic acid and norfloxacin. The ciinicai importance of these changes is uncertain, but is seems iikeiy they wiii oniy be important in the presence of other drugs that aiso affect renai excretion. Grepafloxacin, moxifloxacin, sparfloxacin, and probably ofloxacin, appear not to interact with probenecid. [Pg.340]

Two volunteers, acting as their own controls, took nalidixic acid 500 mg with and without probenecid 500 mg. The peak serum levels of nalidixic acid were unaffected at 2 hours, but at 8 hours the levels were increased threefold by the probenecid. ... [Pg.340]

Another study in 5 women with urinary tract infections treated with nalidixic acid showed that probenecid increased the maximum serum nalidixic acid levels and AUC by 43% and 74%, respectively. ... [Pg.340]

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