Nadolol Erythromycin

Clinically important, potentially hazardous interactions with acebutolol, amiodarone, aspirin, atenolol, atorvastatin, betaxolol, carbamazepine, carteolol, celiprolol, donidine, dabigatran, dantrolene, digoxin, dofetilide, epirubicin, eplerenone, erythromycin, esmolol, eucalyptus, everolimus, lovastatin, metoprolol, mistletoe, nadolol, oxprenolol, penbutolol, pindolol, propranolol, quinidine, ranolazine, sibutramine, simvastatin, timolol, trabectedin... 

Transporter absorptive effects predominant Examples. Acyclovir, Amiloride -, Amoxicillin Atenolol Atropine, Bidisomide Bisphosphonates Captoprit, Cefazolin Cetirizine Cimetidine Ciprofloxacin, Cloxacillin Dicloxacillin Erythromycin - -, Famotidine Fexofenadine Folinic acid Furosemide, Ganciclovir Hydrochlorothiazide, Lisinopril Metformin Methotrexate, Nadolol Penicillins Pravastatin Ranitidine Tetracycline Trimethoprim Valsartan Zalcitabine... 

Svirbely, J.E. Pesce, A.J. TWmethoprim analysis by LC. J.Liq.Chromatogr., 1988,11, 1075—1085 [LOD 50 ng/mL serum plasma dialysate urine CSF SPE interfering atenolol, procainamide, oxazepam non-interfering acetaminophen, amitriptyline, ampicillin, caffeine, cefitoxin, chlordiazepoxide, chlorpheniramine, chlorpromazine, cimetidine, clonidine, desipramine, diazepam, digoxin, diphenhydramine, doxepin, doxylamine, erythromycin, flurazepam, imipramine, lidocEune, minoxidil, nadolol, nortriptyline, prazosin, propranolol, quinidine, theophylline, thioridazine]... 

The serum levels of talinolol and possibly nadolol are increased by erythromycin, but the clinical importance of this is uncertain. Te-lithromycin does not appear to adversely affect sotalol-induced QT prolongation. However, the combined use of sotalol and intravenous erythromycin should generally be avoided because of the possible additive effects on QT interval prolongation. 

A study, in which 7 healthy subjects were given a single 80-mg dose of nadolol after erythromycin 500 mg plus neomycin 500 mg every 6 hours for 2 days, suggested an increase in the rate of beta blocker absorption (reduced time to maximum plasma level, but no effect on AUC). A decrease in the elimination half-life was also seen. More study is needed to determine the clinical significance of these findings. 

Class 3 (Low Permeability, High Solrrbility) Atropine, Aciclovir, Valsartan, Gan-cyclovir, Didanosine, Dicloxacillin, Zaldtabine, Lomefloxacin, Methyldopa, Meth-otrexatum. Nadolol, Pravastatin, Ranitidine, TetracycUne, Famotidine, Cefazolin, Ciprofloxacin, Erythromycin, Atenolol, Hydrochlorothiazide, Metformin. ... 

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