6-n-Propylthiouracil

A small group of cyclic thioureas have been used in the treatment of excessive thyroid function. They include 6-n-propylthiouracil (176 R1 = H, R2 = Prn), 5-iodo-2-thiouracil (176 R1 = I, R2 = H), l-methyl-2-mercaptoimidazole (methimazole) and its ethoxycarbonyl derivative carbimazole (177), which lacks the bitter taste of the unacylated compound. These compounds block the synthesis of thyroxin by inhibiting the oxidation of iodide to iodine and the oxidative coupling of iodotyrosine residues. 

PROPIL-TIOURACILE (ITAIJAN) PROPYCIL 6-PROPYL-2-THIO-2,4(lH,3H)PYRIMIDINEDIONE PROPYL-THIORIST PROPYLTHIOURACIL 4-PROPYL-2-THIOURACIL 6-N-PROPYLTHIOURACIL 6-N-PROPYL-2-THIOURACIL PROPYL-THYRACIL PROPYTHIOURACIL PROTHIUCIL PROTHIURONE... 

PROPYL-THIORIST see PNXOOO PROPYLTHIOURACIL see PNXOOO 4-PROPYL-2-THIOURACIL see PNXOOO 6-PROPYL-2-THIOURACIL see PNXOOO 6-N-PROPYLTHIOURACIL see PNXOOO 6-N-PROPYL-2-THIOURACIL see PNXOOO PROPYL-THYRACIL see PNXOOO n-PROPYLTRICHLOROSILANE see PNX250 PROPYLTRICHLOROSILANE pOT) see PNX250 n-PROPYL-3,4,5-TRIHYDROXYBENZOATE see PNM750... 

Abbreviations CT, Chorda tympani CTX, Bilateral transection of the chorda tympani nerve DRK, Delayed-rectifying potassium FFA, Free fatty acid GL, Glossopharyngeal GLX, Bilateral transection of the glossopharyngeal nerve GPCR, G-protein-coupled receptor LCFA, Long-chain fatty acid PROP, 6-n-Propylthiouracil PTK, Protein tyrosine kinase PUFA, Polyunsaturated fatty acid NST, Nucleus of the solitary tract TG, Triglyceride TRC, Taste receptor cells TRPM5, Transient receptor potential protein 5... 

Drewnowski A, Henderson SA, Shore AB (1997) Genetic sensitivity to 6-n-propylthiouracil (PROP) and hedonic responses to bitter and sweet tastes. Chem Senses 22 27-37 Drewnowski A, Henderson SA, Cockroft JE (2007) Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. J Am Diet Assoc 107 1340-1348... 

Am J Physiol Regul Integr Comp Physiol 285 R447-454 Kirkmeyer SV, Tepper B J (2003) Understanding creaminess perception of dairy products using free-choice profiling and genetic responsivity to 6-n-propylthiouracil. Chem Senses 28 527-536... 

Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ and Bartoshuk LM. (2004) Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res, 28 1629-1637. 

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