N-Methylbenzylamine

Isobutylamine and 2 phenylethylamine can be prepared by the Gabriel synthesis ten butyl amine N methylbenzylamine and aniline cannot... 

Support for initial N alkylation is provided by the reaction of N-isobutenyl-N-methylbenzylamine (26) with methyl iodide, which gave a,a-dimethyb hydrocinnamaldehyde (27) on hydrolysis (ii). 

The N-alkylation of secondary amines was also examined under the same catalytic conditions. Reactions of N-methylaniline and N-methylbenzylamine with benzyl alcohol gave the corresponding tertiary amines in good yields (Scheme 5.20). 

NCA polymerization by secondary amines may involve the amine or activated monomer mechanisms or both mechanisms simultaneously. Unhindered secondary amines such as dimethylamine and piperidine react like primary amines, and polymerization occurs by the amine mechanism. Polymerization by slightly hindered amines such as diethylamine, N-methylbenzylamine, and di-n-propylamine involves a combination of the amine and activated monomer mechanisms. More hindered secondary amines, such as di-n-isopropylamine and dicyclohexylamine, react almost exclusively via the activated monomer mechanism. 

Methylaniline Ethylaniline n-Propylaniline n-Butylaniline Benzylaniline N-Methylbenzylamine. ... 

Fales and Pisano (30) were the first to describe the gas chromatographic analysis of amphetamine. They used 4% SE-30 in a silanized glass column and an argon ionization detector for the separation of (3-phenethylamine, amphetamine, norephedrine, eph drine, histamine, tyramine, dimethyltriptamine, tryptamine, 5-methoxytryptamine, benzylamine, N-methylbenzylamine, octopamine, synephrine, normetanephrine, serotonin, N-acetyltryptamine, find melatonin. The method was also used for the analysis of amphetamine extracted from urine. 

N-Methylbenzylamine Sodium carbonate Propargyl bromide Hydrogen chloride... 

A mixture of 23.8 grams (0.2 mol) of propargyl bromide, 24.2 grams (0.2 mol) of N-methylbenzylamine and 400 ml of anhydrous ethanol in the presence of 42.4 grams (0.4 mol) of anhydrous sodium carbonate was heated at the boiling temperature and under reflux for a period of 17 hours. 

Transmetabttwn activator (2, 403). Mctalations of certain secondary benzyl-amines occur more efliciently using TMEDA-activated n-butyllithium than in mctalations with n-hutyllithium alone. Thus N-methylbenzylamine undergoes dimetalation with n-butyllithium-TMEDA predominantly at the nitrogen and o-benzyl positions. Metalation of olefins. Metalation of 1,1-dime hyl-2,2-diphenylethylene (1) with n-BuI.i-TMEDA complex gives the anion (2) in good yield as shown by the reaction... 

Oxidation of tertiary amines with N-chloronylon 6,6 has also been investigated in several solvents Thus, N-chloronylon has been found to oxidize N J -dimethyl-aniline at room temperature to N-methylaniline in 15—50% yield, depending on the solvent used. The oxidation of NJM-dimethylbenzylamine gives benzddehyde in 15-30% yield and a small amount of N-methylbenzylamine. A comparison of these oxidations with those using the low molecular wei t analoges, e. g. N-chlorosuccin-imide, indicates that in both cases the reaction paths are similar. However, the poor yields observed in these oxidations of amines make these polymeric oxidizing agents unsuitable for amine oxidations. 

Methyl-o-benzoquinone, 76, 251 N-Methylbenzylamine, 406,485 Methyl-N-benzylcarbamate, 343 B-Methyl-9-borabicydononane, 310 Methyl 2,3-butadienoate, 306-307... 

P.23) Benzenemethanamine, A-methyl-, N -methylbenzylamine, benzyl (methyl) amine, benzyl (methyl)azane [103-67-3 ... 

This crude diamine is a 50/50 mixture of meso- and dl-isomers. The mixture also contains 2-5% of N-methylbenzylamine and small amounts of other unidentified contaminants. 

N-Methylbenzylamine Aldrich See Benzylmethylamine Benzylamine, N-methyl- (8) Benzenemethanamine, N-methyl- (9) (103-67-3) N,N-Diethylaniline Aniline, N,N-diethyl- (8) Benzeneamine, N,N-diethyl- (9) (91-66-7)... 

One problem with reductive amination as a method of amine synthesis is that byproducts are sometimes obtained. For example, reductive amination of benzalde-hyde with methylamine leads to a mixture of N-methylbenzylamine and N-mcthyldibenzylamine. How do you suppose the tertiary amine by-product is formed Propose a mechanism. 

Tables VIII and IX show that all of the substituted dibenzyl-amines, N-benzylphenethylamine, and N-benzyl-2-naphthalenemethyl-amine, and all of the secondary amines stimulated the production of poly-cis-carotenes. Tables X, XI, and XII show the ability of substituted N-benzylfurfurylamines N-benzyl,N-methy1furfury1-amines and N-alkyl,N-methylbenzylamines to stimulate the formation of poly-cis-carotenes.

Effect of -alkyl,N-methylbenzylamines on the carotene content of the flavedo of Marsh seedless grapefruit (yg/g dry wt). See caption of Table X for experimental details. 

Schlosser [80] andVoyer [81] reported that N-Boc-N-methylbenzylamine 106 can be deprotonated with 5ec-BuLi in the presence of (-)-sparteine. The resulting organolithium can be trapped with electrophiles to provide a-substituted benzylamines 107 with high enantioselectivities (Scheme 31). Schlosser and coworkers showed that the reaction pathway of N-methyl-hl-Boc benzylamines 107 is an asymmetric deprotonation followed by racemization and asymmetric substitution, and provided rationalization of solvent effects in terms of ion paired species [80]. The enantioselectivity of this reaction sequence is highly dependent on the solvent, electrophile, and reaction time. 

A third motif, also obsei ved in Strouse s TPP materials, is characterized by tightly packed corrugated layers in which the guest molecules intercalate between the layers Zn T(p-Br)PP YG.HvN (aniline) and Zn T(p-Br)PP 2CxH N (methylbenzylamine) (Figure 68). ... 

Many arylations are assisted by functional groups that promote ortho-metallation. Thus, for example, acetanihdes react with arylsilanes at the ortho position via pal-ladacycles 78 and 79 to form derivatives 80 (Scheme 11.27) [84]. Mechanistically, this transformation is similar to a cross-coupling reaction, in which the oxidative addition step is replaced by the ortho-metallation, although in this case the Pd(0) intermediate must be oxidized in situ to generate the reactive Pd(ll) species. Unsubstituted benzylamines and N-methylbenzylamine are ortho-arylated with Pd(OAc)2 in the presence of trifluoroacetic acid (TFA) and silver acetate [85], and a mechanism which differs from the usual Pd(0)/Pd(II) catalytic cycle was suggested for this. Ortho-alkylation was also observed in the palladium-catalyzed... 

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