Myeloperoxidase and

Contain certain unique enzymes (eg, myeloperoxidase and NADPH-oxidase) and proteins... 

Allegra, M. et al.. Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorons acid, Biochem. Biophys. Res. Commun., 332, 837, 2005. 

Lavelli V, Peri C and Rizzolo A. 2000. Antioxidant activity of tomato products as studied by model reactions using xanthine oxidase, myeloperoxidase, and copper-induced lipid peroxidation. J Agric Food Chem 48(5) 1442—1448. 

Miyamoto, G., Zahid, N., and Uetrecht, J.P., Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid, Chem. Res. Toxicol.,10, 414, 1997. 

Nassberger, L. et al., Antibodies to neutrophil granulocyte myeloperoxidase and elastase Autoimmune responses in glomerulonephritis due to hydralazine treatment, J. Intern. Med., 229, 261, 1991. 

The classic oxidizing systems of human myeloperoxidase and horseradish peroxidase were exploited for their well-known abilities to oxidize phenolic substrates. Under conditions of incubations, the following oxidation pathway was defined (155). Peroxidases are first converted to the oxidized... 

The antimicrobial neutrophil proteins are located within intracellular granules. Approximately 30% of all neutrophil granules contain myeloperoxidase, and these azurophilic granules are the first granule types to be... 

Histochemical studies of bone marrow samples show that peroxidase-containing granules are detectable in promyelocytes. The human promyelo-cytic leukaemia cell line HL-60 grows easily in culture, and the cells resemble promyelocytes both structurally and functionally. Furthermore, they can be induced to differentiate in vitro upon addition of various agents, such as retinoic acid and phorbol esters, and these differentiated cells resemble more mature forms of neutrophils. HL-60 cells possess almost the same amount of myeloperoxidase (4.4 fig per 106 cells) as mature neutrophils, and the enzyme purified from these cells has the same subunit structure. The cells thus actively synthesise the enzyme only until they are induced to differentiate. This cell line has been extensively used to study the molecular events controlling the expression of enzymes such as myeloperoxidase, and also to investigate the molecular controls that lead to a cessation of their expression. 

The reaction of myeloperoxidase with H2O2 is complex and depends upon the concentration of H2O2 and the presence of other factor(s) within the microenvironment (Fig. 5.9). The Fe in native myeloperoxidase is in the Fe III (oxidised) state (MP03+, ferric myeloperoxidase), and this reacts with low (equimolar) concentrations of H2O2 to form compound 1, a short-lived inter-... 

The transient production of compounds II and in has been reported during stimulation of neutrophils by fMet-Leu-Phe and PMA, respectively. Ferric myeloperoxidase and compound III show catalase activity, even in the presence of CP, when H2O2 concentrations are in excess of 200 pM. Thus, under these conditions, O2 formation will occur at the expense of HOCI forma-... 

Eastmond DA, Smith MT, Ruzo LO, et al. 1986. Metabolic activation of phenol by human myeloperoxidase and horseradish peroxidase. Mol Pharmacol 30 674-679. 

Mosyagin, L, Dettling, M., Roots, L, Mueller-Oerlinghausen, B. and Cascorbi, I. (2004) Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis. Journal of Clinical Psychopharmacology, 24, 613-617. 

LDL becomes oxidized in vivo. There is evidence that LDL is protected against oxidation in plasma by water-soluble antioxidative substances, such as ascorbic acid, uric acid, or bilirubin. Thus, it is likely that the majority of oxidative modification of LDL occurs in the artery wall, where LDL is largely isolated from the plasmatic antioxidants. Recent evidence suggests that metal ions (copper or iron) and the enzymes myeloperoxidase and lipoxygenase play major parts in the modification of LDL [161]. 

Henderson JP, Heinecke JW (2003) Myeloperoxidase and Eosinophil Peroxidase Phagocyte Enzymes for Halogenation in Humans. In Gribble GW (ed) Natural Production of Organohalogen Compounds, The Handbook of Environmental Chemistry, vol 3, part P. Springer, Berlin, p 201... 

Domigan NM, Charlton TS, Duncan MW, Winterboum CC, Kettle AJ (1995) Chlorination of Tyrosyl Residues in Peptides by Myeloperoxidase and Human Neutrophils. J Biol Chem 270 16542... 

Peroxidases from animal sources which have been studied are thyroid peroxidase, lactoperoxidase, myeloperoxidase and glutathione peroxidase. Lactoperoxidase and... 

Increased levels of myeloperoxidase and phospholipase Increased levels of histamine, 5-HT, leukotrienes, prostaglandins... 

Kimura S, Ikeda-Saito M (1988) Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family. Proteins 3 113-120... 

Amhold J, Furtmuller PG, Regelsberger G et al (2001) Redox properties of the couple compound I/native enzyme of myeloperoxidase and eosinophil peroxidase. Eur J Biochem 268 5142-5148... 

Bakkenist AR, de Boer JE, Plat H, Wever R (1980) The halide complexes of myeloperoxidase and the mechanism of the halogenation reactions. Biochim Biophys Acta 613 337-348... 

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