Multicomponent Reactions in the Synthesis of Target Molecules

Lea Radtke, Eugenia Marques-Lopez and Raquel P. Herrera  

Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland 

Efficiency in total synthesis means the minimization of the number of steps along with a maximum input of structural complexity. In this context, the excellent properties showed 

Compound 23 has good potmcy and selectivity and is orally active as a double prodrug in guinea pigs [16]. Kobayashi and coworkers demonstrated the efficiency of an intermolec-ular Ugi four-component reaction in the synthesis of the naturally derived 20S proteasome inhibitor, omurahde 28 

Multicomponent Reactions Concepts and Applications for Design and Synthesis, First Edition. Edited by Raquel R Herrera and Eugenia Marquds-L6pez. 2015 John Wiley Sons, Inc. Published 2015 by John Wiley Sons, Inc. 

---

Multicomponent reactions represent a flexible tool for the synthesis of a large number of target molecules from three or more starting molecules. They are one-step, one-pot reactions, economic regarding resotrrces and today considered to be close to what is defined as ideal synthesis [1]. Their general synthetic value was recognized when I. Ugi and collaborators reported on some important variants of four-component reactions [2] and their application in the production of known drugs an illustrative example is presented in the next section. 

---