Multi-point recognition

Other reviews deal with aldol additions of group 1 and 2 enolates,103 direct catalytic asymmetric aldol reactions catalysed by chiral metal complexes,104 the exploitation of multi-point recognition in catalytic asymmetric aldols,105 and recent progress in asymmetric organocatalysis of aldol, Mannich, Michael, and other reactions.106... 

Schemes. Donor-acceptor complexes with multi-point recognition motifs DAD ADA 36, DDA AAD 37 and DDD AAA 38 (from Zimmerman and Murray [39])...

It was pointed out over 60 years ago that the recognition of a chiral (or, as subsequently realized, a prochiral) carbon by an enzyme implies that at least three of the groups surrounding the carbon atom must interact with the enzyme. This is the multi-point attachment theory.4 If only two of the groups interact, the other two may be interchanged without affecting the binding of the substrate (structures 8.9). 

Weiss. J. Zinc(II)-porphyrin receptors in multi-point molecular recognition Recent progress. J. Inch Phenom. Macrocycl. Chem. 2001. 40. 1. 

K.M. Kadish, K.M. Smith, and R. Guilard (eds). The Porphyrin Handbook, Vol. 6. Academic Press, Amsterdam, pp. 279-340 e) Weiss, J. (2001). Zinc(II)-porph5Tin receptors in multi-point molecular recognition Recent progress. J. Inclusion Phe-nom. Macrocyclic Chem. 40(1-2), 1-22. 

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