Multi-point attachment theory

It was pointed out over 60 years ago that the recognition of a chiral (or, as subsequently realized, a prochiral) carbon by an enzyme implies that at least three of the groups surrounding the carbon atom must interact with the enzyme. This is the multi-point attachment theory.4 If only two of the groups interact, the other two may be interchanged without affecting the binding of the substrate (structures 8.9). 

Polymer Adsorption. A review of the theory and measurement of polymer adsorption points out succinctly the distinquishing features of the behavior of macromolecules at solid - liquid interfaces (118). Polymer adsoiption and desorption kinetics are more complex than those of small molecules, mainly because of the lower diffusion rates of polymer chains in solution and the "rearrangement" of adsorbed chains on a solid surface, characterized by slowly formed, multi-point attachments. The latter point is one which is of special interest in protein adsoiption from aqueous solutions. In the case of proteins, initial adsoiption kinetics may be quite rapid. However, the slow rearrangement step may be much more important in terms of the function of the adsorbed layer in natural processes, such as thrombogenesis or biocorrosion / biofouling caused by cell adhesion. 

Multipoint attachment theory, 24 247 Multi-point fuel injection system, 10 51 Multiproduct batch processes, 20 723 Multipurpose batch pilot plants, 19 459 Multipurpose canister (MPC), radioactive waste transport in, 25 855 Multipurpose/multiproduct batch plants, 26 1000... 

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