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Multi-drug resistance modulator

Eising EG, Gries P, Eggert J, Scheulen ME. Does the multi-drug resistance modulator cyclosporin A increase the cardiotoxicity of high-dose anthracycline chemotherapy. Acta Oncol (1997) 36, 735-40. [Pg.612]

In addition to the conventional method of making pyrazolones using keto-ester, diethyl 2-(ethoxymethylene)malonate could be used as a surrogate for the keto-esters. As shown below, treatment of phenylhydrazine with diethyl 2-(ethoxymethylene)malonate in ether gave rise to pyrazolols, which was acylated with acyl chloride. The pyrazolols/pyrazolones served as intermediates for the preparation of a potent multi-drug resistance modulator. ... [Pg.219]

Wadkins RM, Houghton PJ (1993) The role of drug-lipid interactions in the biological activity of modulators of multi-drug resistance. Biochim Biophys Acta 1153 225-236... [Pg.248]

Tanabe H, Tasaka SH, Ohmori H, Gomi N, Sasaki Y, Machida T, lino M, Kiue A, Naito S, Kuwano M (1998) Newly synthesized dihydropyridine derivatives as modulators of P-glycoprotein-mediated multi drug resistance. BioorgMed Chem 6 2219-2227... [Pg.249]

Zhao JY, Ikeguchi M, Eckersberg T et al. Modulation of multi-drug resistance gene expression by dexam-ethasone in cultured hepatoma cells. Endocrinology 1993 133 521-8. [Pg.246]

Uterine sarcoma MES-SA is derived from human uterus sarcoma. MES-SA/DX-5 is a multiple drug resistant cell line established from MES-SA cells. These two cell lines are generally used together to study multi-drug resistance and to test modulators to enhance drug delivery across the cell membrane. [Pg.703]

Rahman, A., Husain, S. R., Siddiqui, J., Verma, M., Agresti, M., Center, M., Safa, A. R., Glazer, R. I. Liposome mediated modulation of multi-drug resistance in human HL-60 cells. J. Natl Cancer. Inst. 1992, 84, 1909-1915. [Pg.812]

Thierry, A. R., Vige, D., Coughhn, S. S., Belh, J. A., Dritscilo, A., Rahman, A. Modulation of doxorubicin resistance in multi-drug resistant cells by liposomes. FASEB J. 1993, 7, 572—579. [Pg.812]

Chapter 7 - The ability of amphiphilic block copolymers to modulate multi drug resistance related processes has been demonstrated the first time more than 10 years ago. Nowadays, the efflux pump inhibitory activity of amphiphilic block copolymers is used in two main areas. First, to improve the transport of efflux pump substrates across the blood brain barrier (BBB) and second, in cancer therapy. It has been shown that in the presence of amphiphilic block copolymers higher concentrations of certain anticancer drugs, which are... [Pg.385]

See other pages where Multi-drug resistance modulator is mentioned: [Pg.103]    [Pg.103]    [Pg.78]    [Pg.86]    [Pg.78]    [Pg.50]    [Pg.254]    [Pg.416]    [Pg.184]    [Pg.122]    [Pg.45]    [Pg.322]    [Pg.136]    [Pg.168]    [Pg.94]    [Pg.396]    [Pg.254]   
See also in sourсe #XX -- [ Pg.219 ]



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