Mucosal associated lymphoid tissue

Mucosal-associated lymphoid tissues (MALT) differ in various sites as follows. 

However, the nasal epithelium has little ability to break down drugs. The extensive mucosal surface of the nose has a lining of pseudostratified epithelium as well as cilia and the goblet cells involved in the secretion of mucus. The lymphoid tissue primarily involved in the mucosal immune responses is the mucosal-associated lymphoid tissue (MALT). The different regions of the respiratory tract that play an influencing role in the immune system are as follows ... 

Within the body there may exist at any one time only a handful of naive B lymphocytes capable of recognizing the same epitope. The meeting of an antigen and a naive B lymphocyte capable of recognizing an epitope within the antigen occurs through the delivery of antigen to lymphoid tissues of the spleen, lymph nodes and local lymphoid tissue within mucosal surfaces (mucosal associated lymphoid tissue, MALT) and skin (SALT). This lym-... 

Levy V, Miller C, Koeffler HP, et al. p53 in lymphomas of mucosal-associated lymphoid tissues. Mod Pathol. 1996 9(3) 245-248. 

Mucosal-Associated Lymphoid Tissue (MALT). MALT is pivotally important in local immune responses at mucosal surfaces by providing protection at... 

Mucosal-associated lymphoid tissue (MALT) lymphoma... 

The main site of the mucosal immune system in the gut is referred to as gut-associated lymphoid tissue (GALT), which can be divided into inductive and effector sites. In the small intestine, the inductive sites are in the Peyer s patches, which consist of large lymphoid follicles in the terminal small intestine. The contact with external antibodies triggers a series of cascade events in the body based on immune response (Brandtzaeg et al., 1999). 

Membranous epithelial M cells are a part of the organized mucosa-associated lymphoid tissue (O-MALT). These cells are specialized for antigen sampling. Also, they are exploited as a route of invasion by several pathogens.39 M cells are concentrated in follicle-associated epithelial (FAE) tissue called Peyer s patches in the small intestine. As M cells carry out endocytotic transport, they can be potential vehicles for mucosal drug and vaccine delivery. 

Fig. 11.2. Summary of the host responses to mucosal parasitic infections. Sensitisation occurs initially in gut-associated lymphoid tissue (GALT) various cells of mucosal or peripheral origin are recruited largely by thymus-dependent mechanisms the inflammatory response so generated produces an environment hostile to the continued survival of the parasites. Heavy solid arrows denote possible sources of effector molecules IEL, intraepithelial lymphocytes, some of which are granulated, and probably natural killer cells. (After Befus Bienenstock, 1982, with permission from S. Karger AG, Basel.)...

Perrg X, Cebra JJ, Adler MW, Meissler Jr JJ, Cowarr A, Perrg P, Eiserrsteirr TK (2001) Morphirre irrhibits mucosal arrtibody resporrses arrd TGP- 3 mRNA irr gut-associated lymphoid tissue followmg oral cholera toxirr irr mice. J Immurrol 167 3677—3681. 

Park HS, Francis KP, Yu J, Cleary PP. Membranous cells in nasal-associated lymphoid tissue a portal of entry for the respiratory mucosal pathogen group A streptococcus. J Immunol 2003 171 2532-7. 

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