Mucic

Vigorous oxidation of a monosaccharide (e.g., with dUute nitric acid) produces carboxyl groups at both ends of the chain. Thus galactose gives the sparingly soluble mucic acid glucose affords the soluble saccharic acid, which is best isolated as the sparingly soluble acid potassium salt. 

COoH Saccharic acid 1 CHjOH Galactose 1 COjH Mucic acid... 

Disaccharides, e.g., lactose, which yield galactose upon hydrolysis, will also give the sparingly-soluble mucic acid but in poorer 3deld. This reaction may be employed for the differentiation between certain disaccharides lactose — mucic + saccharic acids sucrose — saccharic acid only maltose — saccharic acid only. 

Dissolve 10 g. of lactose (1) in 100 ml. of nitric acid, sp. gr. 115, in an evaporating dish and evaporate in a fume cupboard until the volume has been reduced to about 20 ml. The mixture becomes thick and pasty owing to the separation of mucic acid. When cold, dilute with 30 ml. of water, filter at the pump and set the filtrate A) aside. Wash the crude acid with cold water. Purify the mucic acid by dissolving it in the minimum volume of dilute sodium hydroxide solution and reprecipitating with dilute hydrochloric acid do not allow the temperature to rise above 25°. Dry the purified acid (about 5 g.) and determine the m.p. Mucic acid melts with decomposition at 212-213°. 

Lactose (hydrated). Lactose (anhydrous) 2031 223 + 52-5 200 — Octa-acetate, a- 152, P- 90 mucic acid, 213... 

Pyrolysis of the methylamine salt (produced by neutralising mucic acid with aqueous methylamlne) in the presence of glycerol yields JV-methylpyrrole ... 

Oxidation of galactose (or a galactose-containing sugar) to mucic acid. Dissolve 1 g. of galactose or lactose in a mixture of 10 ml. of water and 5 ml. of concentrated nitric acid contained in a small evaporating dish, and evaporate the solution to dryness on a water bath. Stir the cold residue with 10 ml. of cold water, filter off the mucic acid, wash it with cold water, dry and determine the m.p. (212-213° with decomposition). 

Mucic acid [526-99-8] Mucoadhesives Muconic acid [505-70-4] Mucopolysaccharidoses Mucor circinelloides Mucor spp. 

Furancarboxylic acid may be prepared by the dry distillation of mucic acid, by the oxidation of furfural with potassium... 

MUchzucker, m. milk sugar, lactose, -agar, m. lactose agar, -saure, /. saccholactic acid (mucic acid). 

Pyro-phosphorsaure, /. pyrophosphoric acid, -saure, /. pyro acid, -schleimsaure, /. pjto-mucic acid, furoic acid, -schwefelsaure, /. pyrosulfuric acid, disulfuric acid (H2S2O7). 

Schleim-saure /. mucic acid, -schicht /. layer of sHme or mucilage or mucus specif., mucous layer, Malpighian layer (of the epidermis). -stoff m. sHmy substance mucin. 

Mucic Acid (Galactaric acid, Galactosaccharic acid, Tetrahydroxyadipic acid, Saccharolactic acid.Schleimsaure (Ger). 

The Synthesis of Some Galactaric (Mucic) Acid Derivatives, K. Butler, D. R. Lawrence, and M. Stacey,/. Chem. Soc., (1958) 740-743. 

Mirkin C.A., Letsinger R.L., Mucic R.C., Storhoee J.J. A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 1996 382 607-609. 

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