Moxonidine Sedatives

CENTRALLY ACTING ANTIHYPERTENSIVES ALCOHOL Clonidine and moxonidine may exacerbate the sedative effects of alcohol, particularly during initiation of therapy Uncertain Warn patients of this effect and advise them to avoid driving or operating machinery if they suffer from sedation... 

TCAs CENTRALLY ACTING ANTI HYPERTENSIVES 1. Possibly hypotensive effect of donidine and moxonidine antagonized by TCAs (some case reports of hypertensive crisis). 2. Conversely, donidine and moxonidine may exacerbate the sedative effects of TCAs, particularly during initiation of therapy 3. Methyldopa may 1 effect of antidepressants 1 and 2. Uncertain 3. Methyldopa can cause depression 1. Monitor BP at least weekly until stable 2. Warn patients of the risk of sedation and advise them to avoid driving or operating machinery if they suffer from sedation. 3. Methyldopa should be avoided in patients with depression... 

The cognitive function of 24 healthy subjects was not impaired by moxonidine 400 micrograms daily, but the presence of moxonidine was found to increase the cognitive impairment caused by lorazepam 1 mg daily. For this reason the manufacturers warn that the sedative effects of the benzodiazepines may possibly be enhanced by moxonidine. Sedation and dizziness may occur with moxonidine, which the manufacturers suggest may be additive with the effects of sedatives and hypnotics. They also advise the avoidance of alcohol. ... 

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