Mouse adrenocortical cells

Schioth et al. (1996) described the pharmacological distinction of the ACTH receptor from other melanocortin receptors in the mouse adrenocortical cell line Yl. Melanocortin receptors do not have a binding epitope for ACTH beyond the sequence of alpha-MSH (Schioth et al. 1997). 

Other cell lines are available for in vitro studies, including the Y1 mouse adrenocortical cell line, with different advantages and disadvantages (for review, see [49]). PC-12 cells are from a rat pheochromocytoma, and they produce norepinephrine and dopamine [60], They have been used to study neuroendocrine signaling of the adrenal medulla and differentiate and stop proliferating following exposure to neural growth factor. Adrenal slices have also been used for short-term experiments, especially those that required the presence of both medulla and cortex, but this model has rarely if ever been used to study toxicity of endocrine disruptors. 

Figure 5. Y1 adrenocortical cells in culture. Y1 mouse adrenocortical tumor cells (a) in the absence and (b) in the presence of 1 mM 8-bromocyclic AMP overnight. (Photos courtesy of Margaret Wong and Dr. Bernard Schimmer.)...

Y1 Mouse adrenocortical tumor Adrenocortical cell Methyl sulfone metabolites of DDT and PCBs Inhibition of corticosterone synthesis by competitive inhibition of cytochrome P450... 

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