Motor neurons, death

Cleveland DW. From Charcot to SOD1 mechanisms of selective motor neuron death in ALS. Neuron 1999 24 525-520. 

Neuronal PCD with features of necrosis was reported in studies of naturally occurring motor neuron death in which the cells exhibited dilation of ER, Golgi and nuclear membranes but not condensation of chromatin. A similar... 

Lee, M. K., Marszalek, J. R. and Cleveland, D. W. A mutant neurofilament subunit causes massive, selective motor neuron death implications for the pathogenesis of human motor neuron disease. Neuron 13 975-988,1994. 

Gould TW, Buss RR, Vinsant S, Prevette D, Sun W, Knudson CM, MilUcan CE, Oppenheim RW (2006) Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALB. J Neurosc. 26(34) 8774-8786... 

In combination with counts of ventral roots, femoral axon counts can be used to distinguish peripheral neuropathy from motor neuron death. The nerve has a primarily motor branch that innervates the quadriceps, and a primarily sensory branch that becomes the saphenous nerve more distally (Fig. 20.5). 

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD 1 ALS model with highest motor neuron death. Proc Natl Acad Sci USA 105, 12599-12604. 

Amyotrophic lateral sclerosis (ALS) is one of the major forms of motor neuron disease (MND), a heterogeneous group of degenerative disorders causing progressive motor neuron death leading to paralysis and death. Amyotrophic lateral sclerosis is a relatively rare disease with a reported population incidence of between 1.5 and... 

Sato M, et al. Cyclosporin A reduces delayed motor neuron death after spinal cord ischemia in rabbits. Ann. Thorac. Surg. 2003 75 1294-1299. 

He BP, Wen W, Sd ong MJ (2002) Acdvated microglia (BV-2) facili-tadon of TNF-alpha-mediated motor neuron death in vido. J Neu-roimmimol 128 31—38. 

IGFs prevent motor neuron death following nerve injury... 

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