Motor neuron diseases characterization

Wong, P. C., Pardo, C. A., Borchelt, D. R. et al. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14 1105-1116,1995. 

Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL (1995) An Adverse property of a familial ALS-linked SODl mutation causes motor neuron disease characterized by vacuolar degeneradon of mitochondria. Neurorr Jurruary 14(6) 1105—1116. 

Motor neuron disease is characterized clinically by weakness, muscle atrophy and spasticity 732... 

The motor neuron diseases (MND), including amyotrophic lateral sclerosis (ALS), are chronic, progressive illnesses characterized by severely disabling clinical features... 

Motor neuron disease is characterized clinically by weakness, muscle atrophy and spasticity. This illness, often termed Lou Gehrig s disease in the United States, is the most common adult-onset form of MND with a prevalence of approximately 2-3 per 100,000 people [1-3,10, 25, 28]. Each year in the United States, in excess of 5,000 people are diagnosed with ALS. In parts of the United Kingdom, 1 in =500 deaths are attributed to some form of MND. The principal clinical signs of ALS include progressive limb weakness, which may be symmetrical or asymmetrical atrophy of appendicular, bulbar and respiratory muscles and spasticity [1,2,26,28]. The paralysis/muscle atrophy and spasticity are the result of degeneration of motor neurons in the spinal cord/brain stem and motor cortex respectively. The onset of this illness is typically in the fifth or sixth decade of life affected individuals usually... 

The neurodegenerative disorders include (1) Alzheimer s disease, the most common cause of dementia, in which the neural injury is primarily in the hippocampus and cortex (2) Parkinson s disease, a disabling motor impairment disorder due to the loss of nigrostriatal dopamine neurons (3) Huntington s disease, a motor disease characterized by excessive and ab-... 

ALS is a neurological disease with damage to motor neurons in the brain and spinal cord. It is characterized by progressive muscle weakness, atrophy, and spasticity. Characteristic neuropathological features include the loss of anterior horn motor... 

ALS Amyotrophic lateral sclerosis is a rare fatal progressive degenerative disease of unknown cause that affects motor neurons, usually begins in middle age, and is characterized by muscular weakness called also Lou Gehrig s disease. 

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