Motility inhibitors

Biological activity and the possible function of the motility inhibitors... 

Phyto chemicals can be used to either stimulate or inhibit motility of the GIT. For example, caffeine and other phytochemicals stimulate motility (Lis-Balchim etal, 2001 Boekema et al, 1999), whereas motility is slowed by peppermint oil (Beesley et al, 1996), protease inhibitors (Schwartz et al., 1994) and several other phytochemicals (Abdullahi et al, 2001 Odetola and Acojenu, 2000 Rojas et al, 1999 Amos et al, 1998). Many of the traditional herbal medicines used for treatment of diarrhea are based on aqueous extracts that slow small intestine transit and increase residence time for digesta (Lin et al, 2002). The opiates and derivatives are particularly noteworthy (Williams et al., 1997). 

Gastrointestinal motility promotors Anti emetics H2 antagonists Phenothiazines 5-ITT inhibitors... 

Chiba, T., Bharucha, A.E., Thomforde, G.M., Kost, L.J., and Phillips, S.F., Model of rapid gastrointestinal transit in dogs effects of muscarinic antagonists and a nitric oxide synthase inhibitor, Neurogastroenterol. Motil., 14, 535, 2002. 

Zhang W, Law RE, Hinton DR, Couldwell WT. (1997). Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. Cancer Lett. 120(1) 31-8. 

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