Montgomery and Asberg Depression

Family therapy and addiction Montgomery and Asberg depression scale... 

Montgomery Asberg Depression Rating Scale (MADRS l (Hamilton. 1959 Montgomery and Asberg, 1979). 

A brief clinical interview covering the symptoms of depression (Montgomery and Asberg 1979). 

The 17-item HDRS is the most commonly used scale in antidepressant clinical trials. This version of the HDRS is heavily weighted toward melancholic symptoms. There are also 21-item, 24-item, and 28-item versions with the additional items assessing nonmelancholic symptoms. The Montgomery-Asberg Depression Scale (MADRS) is another instrument that is frequently used in antidepressant clinical trials. 

Montgomery, S. and Asberg, M. (1979) A new depression scale designed to be sensitive to change , British Journal of Psychiatry, 134 382-9. 

Of 33 patients with chronic hepatitis C treated with interferon alfa, 9 MU/week for 3-12 months, prospectively evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS) before and after 12 weeks of treatment, eight developed depressive symptoms, of whom four had major depression without a previous psychiatric history (381). All four recovered after treatment with antidepressants. This study confirmed that a high baseline MADRS is significantly associated with the occurrence of depressive symptoms. 

Montgomery Asberg Depression Rating Scale (MADRS) Clinician-rated 10-item, 7-point scale. Eor each item 0 = no symptoms 6 = severe symptoms Differentiates between all the intermediate grades of depression. Decreases bias in patients with other medical illness and increased somatization... 

Observational studies In a 6-week, prospective, unrandomized, open study in 20 patients with acute bipolar depression, aripiprazole up to a maximum of 30 mg/ day improved Montgomery-Asberg Depression Rating Scale (MADRS) and Mania Rating Scale (MRS) scores significantly [64 ]. The most fi-equent adverse reactions were nausea and akathisia two patients withdrew because of akathisia. 

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