Mania Rating Scale

Mania/bipolar Mania Rating Scale 7 items rated 0-4 and 4 Cl with Ch/A Fristad et ah, 1992, 1995... 

Mania Rating Scale Public domam. Journal of American Academy of Child Adolescent Psychiatry 1992 31 252—257 (appendix) Multidimensional Anxiety Scale for Children (MASC) Multi-Health Systems Inc., 908 Niagra Falls Blvd., North Tonowanda, NY 14120—... 

Fristad M.A., Weller, E.B., and Weller, R.A. (1992) The Mania Rating Scale Can it be used in children A preliminary report./ Am Acad Child Adolesc Psychiatry 31 252-257. 

Topiramate was also used as monotherapy in an open-label, collaborative, pilot study conducted by three groups of experienced investigators. Eleven acutely manic patients who were nonresponsive to lithium, VPA, or their combination continue to manifest significant symptoms with a mean baseline Young Mania Rating Scales (YMS) score of 32. Five of 11 patients had a substantial response (n = 3) or a partial response (n = 2) to the introduction of monotherapy with topiramate. 

Mania rating scales in particular are likely to show improvement after treatment with any drug with sedative effects. 

In clinical practice in the treatment of bipolar disorder, many agents are used. Comparative or adjunctive efficacy are important considerations. In an open 12-week, randomized assignment study valproate was compared with lithium in 300 patients with acute mania [3 ]. Overall the two drugs reduced manic symptoms equally well, but valproate was superior to lithium in the number of subjects who achieved remission (72% versus 66%, defined as a Young Mania Rating Scale score of less than 12). Both drugs were associated with a 44% adverse effect rate. 

Antipsychotic drugs are more often used in the treatment of bipolar illness. Lithium was equivalent to aripiprazole, and both were superior to placebo, in a 3-week, double-blind, randomized, placebo-controlled study of acutely manic patients [5 ]. The improvement was maintained for an additional 9 weeks (a total of 12 weeks), with a 12.7 point drop in Young Mania Rating Scale score for lithium and a 14.5 point drop for aripiprazole. The most common adverse events with aripiprazole were headache, nausea, akathisia, sedation, and constipation and with lithium nausea, headache, constipation, and tremor. 

Observational studies In a 6-week, prospective, unrandomized, open study in 20 patients with acute bipolar depression, aripiprazole up to a maximum of 30 mg/ day improved Montgomery-Asberg Depression Rating Scale (MADRS) and Mania Rating Scale (MRS) scores significantly [64 ]. The most fi-equent adverse reactions were nausea and akathisia two patients withdrew because of akathisia. 

---