Transporters monosaccharide

Shanahan, M.F., Wadzinski, B.E., Lowndes, J.M., and Ruoho, A.E. (1985) Photoaffinity labeling of the human erythrocyte monosaccharide transporter with an aryl azide derivative of D-glucose. J. Biol. Chem. 260, 10897-10900. 

Noninsulin-dependent diabetes mellitus (NIDDM) is an increasingly common disease, and involves an increase in the capacity of the intestine to absorb monosaccharides. This has been linked to a combination of intestinal structural change with a specific increase in the expression of the monosaccharide transporters SGLTl, GLUT5, and GLUT2 [87]. 

Kida T, Ohe T, Higashimoto H, Harada H, Nakatsuji Y, Ikeda I, Akashi M. Amphi-phihc cyclodextrins as novel monosaccharide transport carriers through a bulk hquid membrane. Chem Lett (Japan) 2004 33 258-259 (in Enghsh). 

Several attempts have been made to facilitate the intestinal absorption and tissue distribution of less permeable componnds by ntilizing monosaccharide transport systems, throngh modification of the parent componnds to sngar analogs. The intestinal brnsh border membrane transport of hexose can be attributed to a Na" /glucose cotransporter (SGLTl) for D-glucose,... 

NGAMPANYA, B., SOBOLEWSKA, A., TAKEDA, T., TOYOFUKU, K., NARANGAJAVANA, J., IKEDA, A., YAMAGUCHI, J., Characterization of rice functional monosaccharide transporter, OsMST5, Biosci. Biotechnol. Biochem., 2003, 67, 556-562. 

Antiparasitic activities have been demonstrated for cytochalasins B (1088), D (1091), E (1096), and for dihydrocytochalasin B, which inhibit growth and differentiation and influence excystation/encystation of the dimoeha. Entamoeba invadens (720). Cytochalasin B (1088) is able also to influence monosaccharide transport systems (721-725) and hormone release (726, 727). Moreover, in 1992, the antiviral cytochalasan L-696,474 (1139, Scheme 14.3) was discovered, exhibiting an inhibitory effect on HIV-1-protease (728-730). 

F. C. Battaglia and P.J. Randle, Regulation of Glucose Uptake by Muscle. IV. The Specificity of Monosaccharide Transport Systems in Rat Diaphragm Muscle, Biochem. J. 75, 408-416 (1960). 

Kolber AR, Krigman MR, Morell P (1980) The effect of in vitro and in vivo lead intoxication on monosaccharide transport in isolated rat brain microvessels. Brain Res 192 513-521... 

The cellular uptake and release of glucose and other monosaccharides is a protein-mediated process. Such proteins are embedded into the cell membrane and can be regarded as hydrophilic pores within the hydrophobic lipid bilayer. Monosaccharide transporters are substrate specific and stereospecific their action is saturable and can be inhibited by specific competitors. Like an enzymatic reaction, the kinetic characteristics can be described by affinity constants and the number of transporter protein molecules determines maximal transport velocity (Vmax)-... 

Knowledge of the tissue-specific expression of monosaccharide transporter proteins helps to define the clinical picture of the different disease entities. Many tissues carry more than one type of transporter and many members of the two monosaccharide transporter families are expressed in more than one tissue. Therefore, congenital disorders of different isoforms of monosaccharide transporters may present with a complex clinical picture... 

Hervonen, H. and Steinwall, O. (1984) Endothelial surface sulfhydryl-groups in blood-brain barrier transport of nutrients. Acta Physiol Scand., 121, 343-351 Kolber, A. R., Krigman, M. R. and Morell, P. (1980) The effect of in vitro and in vivo lead intoxication on monosaccharide transport in isolated rat brain microvessels. Brain Res., 192, 513-521... 

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