Monogenic

Keim, K.R., Miller, F.R. Rosenow, D.T. (1983). Natural selection under diverse environments for monogenic traits in a sorghum composite. Agronomy Abstracts, pp. 69. 

SCA may be envisaged based on biological parameters such as ET-1 and sICAM-1, which are the presently known inter- and intra-individual endothelial cell-related variables in SCA. Ongoing research will hopefully decipher the transcriptional signature of HU in endothelial cells and lead to other treatment options for this simple monogenic yet a complex disorder. 

McBride KL, Gilchrist GS, Smithson WA et al. Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inhibited thiopurine methyltransferase deficiency. J Pediatr Hematol Oncol 2000 22 441-445. Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980 32 651-662. 

Weinshilboum RM, Sladek SL. Mercap-topurine pharmacogenetics monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980 32 651-662. 

Keywords FoUide-stimulating hormone gain of function gonadotropin-releasing hormone (GnRHR) G protein-coupled receptor loss of function luteinizing hormone melanocortin monogenic disease parathyroid hormone rhodopsin thyrotropin. 

Cere- brolysin Neurotrophic factor APOE Prospective Unrelated Cognition One study Monogenic... 

Replicated in two studies One study Monogenic + tiigenic cluster analysis... 

CDP-choline Combination APOE Prospective APOE, ACE dependent Cognition One study Monogenic -1-... 

To understand whether cognitive function and mood disorders are cooperatively influenced by genetic factors in AD and to know the potential impact that conventional neuroprotection can exert on mood disorders, we studied the effect of the therapeutic CNLA protocol on anxiety in AD and the differential APOE- and ACE-related responses distinguishing the influence of monogenic and bigenic variants on emotional conditions. 

Weinshilboun, R.M., and Sladek, S. L. (1980) Mercaptopurine pharmacogenetics monogenic inheritance of erythrocyte thiopuiine methyltransferase activity. Am. J. Hum. Genet. 32,651-662. 

While certain behavioral and nonbehavioral diseases are believed to be monogenic, diseases such as Huntington s, cystic fibrosis, Marfan, and Hirschsprung result in the specified disease, and the outward appearance or result (phenotype) of the disease varies between individuals. For instance, for Marfan syndrome, there is a level below which the mutant protein does not exhibit itself in an outward manner. Most of these diseases have modifier genes that cause modifications in the outward demonstration of the disease and play a key role in the clinical symptoms. Further, the particular metabolic pathways are often varied, with several of the steps being important and the importance of each mechanistic pathway may differ with every individual. 

As noted earlier, there are probably few single gene-associated, or monogenic, diseases and most involve a number of genes. This latter group comprises complex or multifactorial diseases, which are called QTL disorders or diseases. 

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