Mercaptopurine pharmacogenetics

McBride KL, Gilchrist GS, Smithson WA et al. Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inhibited thiopurine methyltransferase deficiency. J Pediatr Hematol Oncol 2000 22 441-445. Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980 32 651-662. [Pg.303]

Weinshilboun, R.M., and Sladek, S. L. (1980) Mercaptopurine pharmacogenetics monogenic inheritance of erythrocyte thiopuiine methyltransferase activity. Am. J. Hum. Genet. 32,651-662. [Pg.410]

Weinshiboum RM, Sladek SL. Mercaptopurine pharmacogenetics Monogenetic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980 32 651-2. [Pg.1285]

Gearry R B, Barclay M L (2005). Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. Gastroenterol. Hepatol. 20 1149-1157. [Pg.1485]

The complex metabolism of azathioprine and mercaptopurine is subject to a pharmacogenetic polymorphism that is relevant to the degree of efficacy and toxicity... [Pg.383]

Adam de Beaumais T, Jacqz-Aigrain E (2012) Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia. Eur J Clin Pharmacol 68 1233-1242... [Pg.704]

PHARMACOGENETICS Favorable responses to azathioprine-mercaptopurine are seen in up to two-thirds of patients. Mercaptopurine has three metabolic fates (1) conversion by xanthine oxidase to 6-thiouric acid (2) metabolism by thiopurine methyltransferase (TPMT) to... [Pg.658]

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