Monocryl

Poliglecaprone-25 is a copolymer of 75% glycoHde and 25% caprolactone. The molecular weight and the percentages of glycoHde and caprolactone are not the same as the coating polymer on Dexon II, but the stmcture (3) is as shown for that polymer. The suture is distributed under the trade name Monocryl. It is claimed to retain approximately 20 to 30% of its strength two weeks after implantation and to be absorbed ia 91 to 119 days. 

Mono-COT compounds, 25 441 Monocots, fibers from, 27 18 Monocotyledonous grains, 26 267 Monocryl sutures, 24 222 Monocyclic monoterpenoid alcohols,... 

Monocryl (Poliglecaprone 25) is a glycolide and -caprolactone copolymer. The thread is nontoxic, but causes a delicate reaction during absorption, which takes place in vivo by way of hydrolysis. 

Monocryl is made from two stages of the polymerization process [Bezwada et al., 1995]. In the first stage, soft segments of prepolymer of glycohde and e-caproladone are made. This soft segmented... 

X 10" Ib-in for Monocryl, while the same size PDSII and Maxon monofilament sutures require about... 

Polycaprolactone (PCL) is a biodegradable semicrystalline polyester that is synthesized from cap-rolactone using staimous octoate in a similar maimer to polylactide or polyglycolide. PCL has a very low modulus of around 50 ksi since it has a low Tg of —60 C. PCL degrades very slowly, and therefore, it is usually not used as a homopolymer. Caprolactone, however, is copolymerized with glycolide to make a flexible suture material (trade name Monocryl). ... 

Poly(glycolide-co- -caprolactone) copolymer (Monocryl , Monocryl Plus , Suruglyde )... 

The most important aspect of Monocryl monofilament suture is its pliability as claimed by Ethicon (Bezwada et al, 1995). The force required to bend a 2/0 suture is only about 2.8 x 10 Ib-in (193 MPa) for Monocryl, while the same size PDSII and Maxon monofilament sutures require about 3.9 and 11.6 X lO Ib-in (269-800 MPa) force, respectively. This inherent pliability of Monocryl is due to its low glass transition temperature resulting from the... 

Biosyn has tissue reaction between Monocryl (lower end) and PDSII (higher end) (Molea et al., 2000). For example, the tissue reaction scores of Monocryl, Biosyn, and PDSII at the end of 3 months were 8,20, and 28. However, at the end of 6 months, the tissue score of Biosyn was very close to that of Monocryl (7 vs 5), while PDS had a score of 20, an indication that both Biosyn and Monocryl were essentially completely absorbed. 

Bezwada R S, Jamiolkowski D D, Erneta M, Persivale J, Trenka-Benthin S, Lee IY, Suryadevara J, Yang A, Agarwal V and Liu S (1995), Monocryl suture, a new ultra-pliable absorbable monofilament suture . Biomaterials, 16,1141. 

Po ly( g lyco 1 i de/c-ca pro 1 acto ne) copolymer at 75% glycolide and 25% c-caprolactone Poliglecaprone 25 Monocryl plus antibacterial Monofilament... 

---