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Monoclonal antibody immunotoxins

Ghetie, V., Ghetie, M.-A., Uhr, J.W., and Vitetta, E.S. (1988) Large scale preparation of immunotoxins constructed with the Fab fragment of IgGl murine monoclonal antibodies and chemically deglyco-sylated ricin A chain./. Immunol. Meth. 112, 267-277. [Pg.1066]

Lambert, J. M., Senter, P. D., Yau-Young, A., Blattler, W. A., and Goldmacher, V.S. (1985) Purified immunotoxins that are reactive with human lymphoid cells monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins./. Biol. Chem. 260,12035—12041. [Pg.720]

Ricin is a type II toxin. The A chain (ricin A) contains 267 amino acid residues, and the B chain (ricin B) 262 residues. Ricin A is exceptionally toxic, and it has been estimated that a single molecule is sufficient to kill an individual cell. This peptide can be prepared by genetic engineering using Escherichia coli. The potent action of this material on eukaryotic cells has been investigated in anticancer therapy. Ricin A has been coupled to monoclonal antibodies and successfully delivered specifically to the tumour cells. However, in vitro toxicity of ricin A-based immunotoxins is enhanced significantly if ricin B is also present. [Pg.434]

The development of monoclonal antibodies (mAbs) has revolutionized cancer treatment, and several mAbs are today approved for clinical use. Treatment resistance is often a problem in mAbs-treatment where multiple treatment series are necessary [100]. Dmg response can be increased by binding mAbs to cytotoxic compounds, such as protein toxins, forming immunotoxins (ITs) [101]. The historical problems with first and second generation ITs are largely solved by the use of recombinant DNA technology where chimeric proteins consisting of the Fv-ffagment of an antibody and... [Pg.275]

Human monoclonal antibodies are on the market both for therapeutic and diagnostic purposes. Why is it then necessary to develop immunotoxins ... [Pg.130]

Myers, D., Yanishevski, Y., Masson, E., Irvin, J., Evans, W., and Uckun, F. (1995) Favorable pharmacodynamic features and superior anti-leukemic activity of B43 (anti-CD19) immunotoxins containing two pokeweed antiviral protein molecules covalently linked to each monoclonal antibody molecule. Leuk. Lymphoma 18, 93-102. [Pg.36]

Rybak, S. M. and Youle, R. J. (1991) Clinical use of immunotoxins monoclonal antibodies conjugated to protein toxins. Immunol. Allergy Clin. N. Am. 11(2), 359-380. [Pg.93]

XomaZyme-791 (XZ-791) is a monoclonal antibody coupled to an immunotoxin, Ricin toxin A, devel-... [Pg.147]

Byers, V.S., Rodvien, R., Grant, K., Durrant, L.G., Hudson, K.H., Baldwin, R.W., and Scannon, P.J. Phase I study of monoclonal antibody-Ricin A chain immunotoxin Xoma-zyme-791 in patients with metastatic colon cancer. Cancer Research 1989 49 6153-6160. [Pg.367]

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See also in sourсe #XX -- [ Pg.452 ]



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