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Immunotoxins construction

Ghetie, V., Ghetie, M.-A., Uhr, J.W., and Vitetta, E.S. (1988) Large scale preparation of immunotoxins constructed with the Fab fragment of IgGl murine monoclonal antibodies and chemically deglyco-sylated ricin A chain./. Immunol. Meth. 112, 267-277. [Pg.1066]

Kondo K, FitzGerald DJ, Chaudhary V. Activity of immunotoxins constructed with modified pseudomonas exotoxin a lacking the cell recognition domain. / Biol Chem 1988 263 9470-5. [Pg.664]

A variant of the original immunotoxin approach is the so-called immunocytokines. In these constructs the antibody targeting moiety is maintained, but the toxin as the effector molecule is replaced by a cytokine. In contrast to toxins, cytokines are often proteins endogenously produced in man. If both the antibody and cytokine are of human origin, then no foreign proteins are introduced which could provoke an antibody response from the host immune system when the drug targeting preparation is clinically applied. [Pg.299]

ITABLE 13.10. Properties of toxins often used in construction of immunotoxins... [Pg.364]

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