Monobenzone

C7H7Br 100-39-0) see Fosinopril Latanoprost Monobenzone Orlistat Pirbuterol Saquinavir benzyl bromoacetate... 

A physician ordered 20% monobenzone (Benoquin ) ointment to be used for the temporary bleaching of hyperpigmented skin. In what proportion may 25%, 10%, and 5% monobenzone ointments be mixed in order to prepare an ointment of the desired concentration ... 

Mecfianism of Action The mechanism of action is not fully understood. Monobenzone maybe converted to hydroquinone, which inhibits the enzymatic oxidation of tyrosine to DOPA it may have a direct action on tyrosinase, or it may act as an antioxidant to prevent SH-group oxidation so that more SH groups are available to inhibit tyrosinase. Therapeutic Effect Depigmentation in extensive vitiligo. 

Hydroquinone, monobenzone(BENOQUIN),trioxsalen (NEOSORALEN), methoxsalen(MACSORALEN), azelaic acid... 

AGENTS AFFECTING PIGMENTATION HYDROQUIN ONE, MONOBENZONE, MEQUINOL... 

Hydroquinone, monobenzone (Benoquin, the monobenzyl ether of hydroquinone), and mequinol (the monomethyl ether of hydroquinone) are used to reduce hyperpigmentation of the skin. Topical hydroquinone and mequinol usually result in temporary lightening, whereas monobenzone causes irreversible depigmentation. 

The mechanism of action of these compounds appears to involve inhibition of the enzyme tyrosinase, thus interfering with the biosynthesis of melanin. In addition, monobenzone may be toxic to melanocytes, resulting in permanent loss of these cells. Some percutaneous absorption of these compounds takes place, because monobenzone may cause hypopigmentation at sites distant from the area of application. Both hydroquinone and monobenzone may cause local irritation. Allergic sensitization to these compounds can occur. Prescription combinations of hydroquinone, fluocinolone... 

Depigmenting agent Monobenzone Benoquin Cetyl alcohol NF Sodium lauryl sulfate NF... 

Monobenzone can cause contact aUergies that, oddly enough, occur mainly on areas of normal color skin and very rarely on the vitiligo patches. Fifteen per cent of patients develop skin rashes. Sun protection must be worn permanently, as the skin loses all its melanin protection. 

Nevertheless, there are still some monobenzone depig-menting creams on the market they have low concentrations of monobenzone (around 1.5%). Nevertheless, some highly concentrated means at 20% can be found on the market. When applied to the hands, there have been cases of permanent, confetti-like depigmentation that has spread to the forearms. ... 

Monobenzone is therefore not indicated in the treatment of freckles, melasma, age spots, PIH and other dyschromias, apart from cases of severe vitiligo that resists attempts at repigmentation. 

Hedges TR, Kenyon KR, Hanninen LA, Mosher DB. Corneal and conjunctival effects of monobenzone in patients with vitiligo. Arch Ophthalmol 1983 101 64-8. 

Nordlund JJ, Forget B, Kirkwood J, Lerner AB. Dermatitis produced by application of monobenzone in patients with active vitiligo. Arch Dermatol 1985 121 1141-4. 

Catona A, Lanzer D. Monobenzone, superfade, vitiligo and confetti-like depigmentation. Med J Aust 1987 146 320-1. 

Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Chemically, hydroquinone is designated as p-dihydroxybenzene the empirical formula is C6H602. 

Monobenzone is the monobenzyl ether of hydroquinone. Chemically, monobenzone is designated as p-(benzy-loxyjphenol the empirical formula is C13H1202, molecular weight 200.24. Each gram of benoquin cream contains... 

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