Monitoring, bioprocesses, advances

In a review paper devoted to the chemometrics discussed in previous citations, Shaw et al.28 go into details of the many applications of advanced chemometrics to bioprocess monitoring. Multivariate methods and numerous algorithms are explored in this work. 

This is particularly true in the case of bioprocesses where the state of the living part of the system must be closely monitored. Extensive surveys have been published and several international conferences have been held on this topic. Furthermore, the last two decades have seen an increasing interest to improve the operation of bioprocesses by applying advanced control schemes. In particular, biological Wastewater Treatment Processes (WWTP s), more efficient than the traditional physico-chemical methods but at the same time... 

D. Dochain and M. Perrier. Advanced Instrumentation, Data Interpretation, and Control of Biotechnological Processes, chapter Monitoring and Adaptive Control of Bioprocesses, pages 347-400. Kluwer Academic Publishers, 1998. 

Pease, M.D. Shriver-Lake, L.C. Ligler, F.S. In Recent Advances in Biosensors, Bioprocess Monitoring, and Bioprocess Control, K.R. Rogers, A. Mulchandani W. Zhou, Eds. ACS Symposium Series American Chemical Society, Washington, D.C., 1995, (this vol). 

ZHOU MULCHANDANI Recent Advances in Bioprocess Monitoring... 

This volume presents a cross section of recent advances in the development of novel chemical and biochemical sensors for on-line monitoring and control applications in the environmental, clinical, and bioprocess areas. These chapters illustrate how many of the key challenges for continuous monitoring are being addressed. The methods discussed include optical techniques ranging from near-infrared spectroscopy to lifetime-based phase fluorometry biosensors ranging from optical immu-nosensors to enzyme-electrodes as well as electrochemical, acoustic, and plasmon resonance techniques. 

Schuster KC (2000) Monitoring the physiological status in bioprocesses on the cellular level. Advances in Biochemical Engineering/Biotechnology 66 185-208. 

Luchner, M., Gutmann, R., Bayer, K. et al. (2012) Implementation of proton transfer reaction-mass spectrometry (PTR-MS) for advanced bioprocess monitoring. Biotech-nol. Bioengin. 109, 3059. 

---