Molecular testing approach

Molecular diagnostics approaches to carrier status for Duchenne muscular dystrophy are based on the discovery of the presence of a deletion in the gene for dystrophin. Sometimes, the testing approach provides a probability or likelihood estimate of an individual being a carrier (e.g., the use of indirect or linkage analysis for DMD when a deletion is not detectable), rather than clear documen-... 

Mercer IP, Abend S, Gould IR, Klug DR. A quantum mechanical/molecular mechanical approach to solvation dynamics tested by three pulse photon echo measurements. In Elsaesser T, Fujimoto JG, Wiersma DA, Zinth W, eds. Ultrafast Phenomena, Berlin Springer-Verlag, 1998 532-534. 

Agrawal, V.K. and Khadikar, P.V. (2002) QSAR study on narcotic mechanism of action and toxicity a molecular connectivity approach to Vibrio fischori toxicity testing. Bioorg. Med. Chem., 10, 3517-3522. 

The work was continued on the paper chromatography modeling of UF oligomers [72]. In this series of experiments the limits of the molecular mechanics approach finally started to become apparent. While a good trend correspondence with experimental Rf values was again obtained within each of the two series of UF oligomers tested, correspondence was lost when one tried to compare the compounds within a series with the compounds of the other series. Thus, excellent correspondence existed within the homo-... 

The KSR and Rouse models were subj ected to numerous experimental tests. A reasonably good agreement between the theoretical predictions and experimental data was demonstrated for a variety of dilute polymeric solutions. Further advance in the molecular-kinetic approach to description of relaxation processes in polymeric systems have brought about more sophisticated models. They improve the classical results by taking into account additional factors and/or considering diverse frequency, temperature, and concentration ranges, etc. For the aims of computer simulation of the polymeric liquid dynamics in hydrodynamic problems, either simple approximations of the spectrum, Fi(A), or the model of subchains are usually used. Spriggs law is the most used approximation... 

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