Molecular signalling mechanisms immune response

The molecular mechanisms of these phenomena are not fully understood. However, one hypothesis is that the combination of linear DNA with a cross-linked peptide may be interpreted as a danger signal, evoking a strong immune response. 

The issue of biocompatibility must be addressed to ensure that nanoscale biotic constructs demonstrate viability, longevity, and shelf-life in the artificial environment of a deployable sensor. This is especially important for applications such as implantable sensor nanodevices, tissue engineering, and drug-delivery systems. Research to understand, predict, and enable to the ability to nanomaterials to interact without eliciting negative immune, systematic, or other cellular responses in performance as a substrate that will support the cellular activity and will facilitate molecular and mechanical signaling systems is needed. 

---