Molecular Recognition and Supramolecular Chemistry

Such complexes are sometimes called supramolecules. The choice of which molecule is the host and which is the guest is somewhat arbitrary, but the larger molecule is usually deemed the host. Enzyme-substrate complexes are a prime biochemical example of such interactions. Cram, Pedersen, and Lehn shared the 1987 Nobel Prize in chemistry for their pioneering work in the area of molecular recognition and supramolecular chemistry. The recent chemical literature is replete with examples in which NMR has been used to study such complexa-tion.6... 

The successful trapping and subsequent immobilization of the 2-1" inclusion complex on gold surfaces demonstrates that the ideas and concepts common to the fields of molecular recognition and supramolecular chemistry can also be utilized to assemble novel structures at the electrode-solution interface. 

Boronic acids, both alky and aryl, have been available for around 150 years. Currently, the most common method used to prepare boronic acids is the reaction of trialkyl borates with Grignard reagents. While boronic acids are widely used in synthetic chemistry, the aim of this chapter is to introduce the use of boronic acids in molecular recognition and supramolecular chemistry. 

Schalley, C.A. (2001) Molecular recognition and supramolecular chemistry in the gas phase. Mass Spectrom. Rev., 20, 253-309. 

The breakthrough came when it was realized that the concepts of molecular recognition and supramolecular chemistry could be put to use to make catenane synthesis a rational and efficient processes. Two independent strategies—the use of metal complexation chemistry and TT donor-acceptor forces in organic systems—were exploited to make novel structures. 

This book is dedicated to the memory of Professor Hiroshi Tsukube, who made significant contributions to the fields of molecular recognition and supramolecular chemistry. His work and efforts continue to be an inspiration to those working in the field. 

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