Boronic acid preparation

We have broadened the scope of this reverse addition protocol to prepare a variety of boronic acids bearing different functional groups for use in Suzuki coupling reactions. The yield and quality of the boronic acid prepared by this reverse addition protocol is usually better than the sequential approach. The boronic acids can be used without further purification (formation of pinacols) in Suzuki coupling reactions. 

Hall, D. G. (2005). Boronic Acids Preparation and Applications in Organic Synthesis and Medicine. Wiley-VCH Verlag GmbH, Weinheim, (1) 17-18. 

Boronic Acid Preparation/Suzuki Cross-Coupling... 

TBS and 1-TIPS indole-3-boronic acids, prepared in situ via halogen exchange, conple weU with a range of heterocyclic snbstrates. ... 

Involving a Suzuki reaction, Hodge prepared chemical robust polymer-supported diphenyl prolinol based catalysts 68 and 69 from 62 and 63 and polystyrene boronic acid prepared via a direct lithiation of 1% crosslinking gel-type polystyrene beads (2.21 mmg/mol of boronic acid residue) (Scheme 31) [59]. 

D.G. Hall, Boronic Acids Preparation and Applications in Organic Synthesis, Medicine and Materials, second ed., WUey-VCH, Weinheim, Germany, (2011). 

D. Hall (Ed.), Boronic acids preparation and applications in organic synthesis and medicine, Wiley-VCH Verlag GmbH, Weinheim, Germany, 2005. 

R. A. Batey in Boronic acids preparation and applications in organic synthesis and medicine (D. Hall, Ed.). Wiley-VCH Verlag GmhH, Weinheim, Germany, 2005, pp. 279-304. NucleophUic addition reactions of aryl and alkenylboronic acids and their derivatives to imines and iminium ions. 

Hall DG. Boronic Acids—Preparation, Applications in Organic Synthesis and Medicine. Weinheim WUey-VCH 2005. 

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