Molecular inclusion

J. Rebek, Jr., iu E. Weber, ed.. Molecular Inclusion and Molecular Recognition—Clathrates II, Top. Curr. Chem. Vol. 149, Springer, Bedia-Heidelberg, 1988, p. 189. 

E. Weber, editor. Molecular inclusion and molecular recognition— Clathrates 1, volume 140 of Topics in Current Chemistry. Springer Verlag, Berlin, 1987. 

Molecular inclusion and molecular recognition — clathrates II. (Topics in current chemistry 149)... 

Molecular Inclusion and Molecular Recognition — Clathrates I Preface... 

This book is the second of a two-volume series that attempts to bring together in-depth investigations in currently important areas of molecular inclusion and molecular recognition mainly based on clathrate formation. The first volume of this series (Volume 140) was published in 1987. 

Figure 1 shows the crystal structure of the 5,10 12,17 19,24 26,3-tetrakis (dimethyl-siladioxa)-l, 8,15,22-tetramethyl[l4]metacyclophane cavitand (7) which has an enforced cavity appropriately sized to include only slim linear guests 12b). This cavitand forms crystals of a 1 1 molecular inclusion complex with CS2, the guest species being almost entirely encapsulated within the host cavity 27). The crystal structure of the complexed... 

Weber, E. 4th International Symposium on Molecular Inclusion Phenomena, Lancaster, England (1986)... 

Additional clathrate inclusions of this particular type of functional group free hosts have been studied by Toda and coworkers (see Chapter 3 in Vol. 140 of this series, Molecular Inclusion and Molecular Recognition — Clathrates I ). 

Molecular inclusion and molecular recognition Clathrates I II , Topics in Current Chemistry, Vol. 140 and 149 (Ed. E. Weber), Springer-Verlag, New York, 1987 and 1988. 

Soft and topologically adaptable supramolecular modules that allow host lattices to achieve dense packing through low-energy deformations, while retaining their inherent dimensionality and supramolecular connectivity, can facilitate the systematic design of molecular inclusion compounds. This is demonstrated by the ability to predict and maintain architectural control in a series of lamellar host frameworks. 

The first direct evidence for molecular inclusion came from X-ray crystallography. Hybl and coworkers determined the structure of the alpha cyclodextrin-potassium acetate complex by using three-dimensional X-ray diffraction data. They found that, in the solid state, the acetate anions are included by the alpha cyclodextrin. In the process, they also found that every D-glucosyl residue of the alpha cyclodextrin is in the C conformation. 

Reviews Molecular Inclusion and Molecular Recognitions-Clathrates 1 and 2 Top. Curr. Chem. 140 (1987) and 149 (1988). 

Figure 30. Slopes (a) and intercepts (7A5o) obtained for a variety of cation binding closed circle), molecular inclusion lightly shadowed in italic), and biological supramolecular interaction shadowed in bold).

Itraconazole oral solution contains 10 mg of itraconazole per milliliter, solubilized by hydroxypropyl-(beta)-cyclo-dextrin (400 mg/mL) as a molecular inclusion complex. The solution is clear and yellowish in color with a target... 

Effects of Encapsulation by Spray-Drying, Extrusion, and Molecular Inclusion... 

Spray drying, extrusion, coacervation and adsorption techniques are among the more widely used (1 ), A relatively new method is the molecular inclusion of flavor in beta-cyclodextrin (2, 3). 

Little work has been published comparing the shelf life of flavors encapsulated by different processes. The purpose of this investigation was to determine the shelf life of cold pressed orange oil encapsulated by spray drying, extrusion, and molecular inclusion. Limonene-1,2-epoxide concentration was used to monitor oxidation. 

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