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Molecular function derivation

Research and development efforts in the pharmaceutical and biotech industries depend critically on patent protection for commercially valuable biological molecules. In this context, patent laws broadly require clear disclosure of molecular function. Deriving this essential functional information is far from trivial [101]. Basic sequence homology studies are already a first step in these critical research efforts. Pattern-based approaches focusing on fundamental structural and functional motifs can valuably focus expensive and lengthy laboratory efforts. The power of these approaches will invariably increase with expansion and improvement of data repositories and associated analysis tools. The U.S. Patent and Trademark Office already welcomes these sorts of in silico studies as valuable adjunct evidence in support of a molecule s functional specification. [Pg.35]

In a related way, ensemble molecular dynamics derives a pharmacophore using restrained molecular dynamics for a collection of molecules. A force field model is set up so that none of the atoms in each molecule sees the atoms in ainy other molecule. This enables the molecules to be overlaid in space. A restraint term is included in the potential, which forces the appropriate atoms or functional groups to be overlaid in space. [Pg.669]

One of the most important molecular functions of p53 is therefore to act as an activator of p21 transcription. The wild-type protein binds to specific DNA sequences, whereas tumor-derived p53 mutants are defective in sequence-specific DNA binding and consequently cannot activate the transcription of p5 3-con trolled genes. As we will see more than half of the over one thousand different mutations found in p53 involve amino acids which are directly or indirectly associated with DNA binding. [Pg.166]

As illustrated in Fig. 2, these complexes are likely dimeric. Curiously, only when in TORC1 is TOR/mTOR bound and inhibited by the rapamycin-FKBP12 complex. Rapamycin has been an incredibly important tool to dissect the molecular function of TORC1/mTORCl and as outlined below, rapamycin and related derivatives have ever-increasing clinical potential. No small molecule inhibitor of TORC2/mTORC2 has been identified and consequently understood the functions of this complex is relatively less well developed. [Pg.1213]

Barboiu, M Hovnanian, N., Luca, C. and Cot, L. (1999) Functionalized derivatives of benzo-crown-ethers, V, Multiple molecular recognition of zwitterionic phenylalanine. Tetrahedron, 55, 9221—9232. [Pg.335]

Molecular scaffoldings with tetraethynylethenes (TEEs, 3,4-diethynylhex-3-ene-l,5-diynes) and trans-1,2-diethynylethenes [DEEs, (E)-hex-3-en-l,5-diynes] are at a particularly advanced stage.114,37 38 441 A collection of dose to one hundred partially protected and functionalized derivatives have been prepared in the meantime, providing starting materials for the perethynylated dehydroannulenes and expanded radialenes shown in Figure 6.136 441 TEEs and DEEs, as well as dimeric derivatives substituted at the terminal alkynes with donor (D, p-(dimethyl-... [Pg.170]

Polycondensation of diols with dicarboxylic acids is often performed in the melt. However, it does not always lead to high-molecular-weight polyesters. Sometimes, the starting materials or the resulting polyester are thermally unstable at the high condensation temperatures. If the reactants and the polyester are well soluble, one can carry out the polycondensation in solution (see Example 4-2). The elimination of water from diols and dicarboxylic acids frequently occurs rather slowly. In such cases suitable functional derivatives of the diols and dicarboxylic acids (esters or anhydrides) can be used instead of the direct condensation, as described in Sect. 4.1.1.3. [Pg.272]

The covalent chemistry of fullerenes has developed very rapidly in the past decade in an effort to modify fuUerene properties for a number of applications such as photovoltaic cells, infrared detectors, optical limiting devices, chemical gas sensors, three-dimensional electroactive polymers, and molecular wires [8, 25, 26, 80-82]. Systematic studies of the redox properties of Cgo derivatives have played a crucial role in the characterization of their unique electronic properties, which lie at the center of these potential applications. Furthermore, electrochemical techniques have been used to synthesize and separate new fullerene derivatives and their isomers as well as to prepare fullerene containing thin films and polymers. In this section, to facilitate discussion of their redox properties, Cgo derivatives have been classified in three groups on the basis of the type of attachment of the addend to the fullerene. In group one, the addends are attached via single bonds to the Cgo surface as shown in Fig. 6(a) and are referred to as singly bonded functionalized derivatives. The group includes... [Pg.159]

The interaction of the metal alkoxides with the salts of carboxylic acids or with p-diketonates of other metals is especially attractive for the synthesis of bimetallic molecular precursors in the cases, when the preparation of the alkoxide of the other metal is somehow hindered or it is insoluble or irreactive under the conditions applied. This method has been widely used for the sol-gel preparation of HTSC materials (because of low solubility and reactivity of Cu(OR)2) and lead-containing ferroelectrics (in the view of difficult synthesis and low stability of Pb(OR)2). It should be mentioned that the reaction between a metal alkoxide and a functional derivative does far not always lead to the formation of a mixed-ligand bimetallic complex ... [Pg.90]

As with the Schrodinger equation itself, the most useful estimate of the form of the potential well in real molecules was an inspired hypothesis, rather than a function derived rigorously from first principles. The Morse Curve is a very realistic approximation to the potential energy well in real molecular bonds. [Pg.46]


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See also in sourсe #XX -- [ Pg.75 , Pg.76 , Pg.77 , Pg.78 ]




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