Molecular Biology Database Collection

Galperin, M. Y. 2004. The molecular biology database collection 2004 update. Nucleic Acids Res 32 D3-22. 

NAR 2004 Molecular Biology Database Collection (http //nar.oupjoumals, org/cgi/content/full/32/suppl l/D3/DCl)... 

Galperin, M. 2005. The Molecular Biology Database collection 2005 update. Nucleic Acid Res 33 D5-24. 

Baxevanis, A. D. (2001). The Molecular Biology Database Collection An Updated Compilation of Biological Database Resources. Nucleic Acids Res. 29, 1-7. 

The Molecular Biology Database Collection 2002 Uptkte," AndreasD. Baxevanis, A.D. NucUie Adds Research 2002,30(1)1 12. 

GenBank is the NIH genetic sequence database, and an annotated collection of all publicly available DNA sequences. It is part of the International Nucleotide Sequence Database Collaboration, which comprises the GenBank at NCBI, DNA DataBank of Japan (DDBJ), and the European Molecular Biology Laboratory (EMBL). These three organizations exchange data on a daily basis. 

Experimental infections, tissue collection, extraction conditions, purification procedures, and strategies for determining the primary structure of the natural bioactive peptides should be adapted to the animal model (size, rarity, possibility to conduct molecular biology investigations, availability of EST, and genomic databases, etc.) considered and to the complexity of the bioactive peptide. 

As mentioned in the introduction, there is now a considerable number of molecular biology and related databases available. While some are freely available, such as the DNA sequence collection EMBL [30] and GENBANK [18], others are only freely available to the academic community, such as the protein sequence database SWISS-PROT [15], and others are only available on subscription, such as the EST databases available from the company Incyte Genomics. Academics and pharmaceutical companies also have their own proprietary data which must be integrated into a system so that relationships with publicly available data can be found. 

EMBL Data Library The main role of the European Molecular Biology Laboratory Data Library, currently known as EBI, is to maintain and distribute a database of nucleotide sequences. This work is a collaborative effort with GenBank and DNA Database of Japan (DDBJ) where each participating group collects a portion of the total reported sequence data. 

The Internet has become the major information resources for biological sciences (Duscart, 2002). One of the most valuable web resources for scientific literatures is PubMed (www.ncbi.nhn.nih.gov/PubMed/), which is accessible from Entrez at http //www.ncbi.nhn.nih.gov/entrez. PubMed is provided by the National Library of Medicine, which is part of the National Institute of Health (NIH). Mauy well-regarded journals in biochemistry, cell biology, molecular biology and related fields as well as clinical publications of interest to medical professionals are indexed in PubMed. The resource can be searched by a keyword entry with the Boolean operators (AND, OR and NOT). Users can specify which database fields to check for each search term. The Preview/Index menu allows the user to build a detailed query interactively. The clipboard allows the user to collect and save individual search results. 

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