Mogadon - Nitrazepam

Other benzodiazepines have been used as AEDs but are not approved for this use in the United States. They include lorazepam Ativan), nitrazepam Mogadon), and clobazam UrbaniJ). It is unlikely that these drugs offer any advantages over similar agents. 

OFFICIAL NAMES Alprazolam (Xanax), chlorazepate (Tranxene) chlordiazepoxide (Librium, Novopoxide), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium, Vivol), estazolam (ProSom), flurazepam (Dalmane, Novoflupam, Somnol), flunitrazepam (Rohypnol), halazepam (Paxipam), lorazepam (Ativan), nitrazepam (Mogadon), oxazepam (Serax), prazepam (Centrax), quazepam (Doral), temazepam (Restoril), triazolam (Halcion)... 

In particular, individuals taking nitrazepam (Mogadon) often report an increase in the incidence of nightmares, especially during the first week of use. Flurazepam (Dalmane, Novoflupam, Somnol) also occasionally causes an increase in nightmares, as well as anxiety, irritability, tachycardia, sweating, and garrulousness. 

In estimated deaths per million patients, the rank order among all BZs in Britain was dominated by the hypnotics. Dalmane (90 per million) was first, Restoril (71) was second, the British hypnotic flunitrazepam (Rohypnol 49) was third, and Halcion (30) was fourth. Another British hypnotic, nitrazepam (Mogadon and others 26) was fifth. 

However, functional groups refuse to be stereotyped. Nitrazepam also contains a nitro group, but this compound is marketed as Mogadon , the sleeping pill. 

In this article, only the properties of the five most important benzodiazepines will be dealt with in some detail although the recently introduced substances of this class have been also studied polarographically and analytical methods have been suggested for them by the Frankfurt school [223-228]. At present classical benzodiazepines are chlorodiazepoxide (1, Librium), diazepam (2, Valium), oxazepam (3, Serenid D), nitrazepam (4, Mogadon) and dipotassiumchlorazepate (5, Tranxillum). 

The generic names diazepam, nitrazepam, flur-azepam are all of benzodiazepines. Their proprietary names are Valium, Mogadon and Dalmane respectively. Names ending in -olol are adrenoceptor blockers in -pril are ACE-inhibitors in -floxacin are quinolone antimicrobials. 

Nitrazepam (Mogadon)was the first benzodiazepine marketed in 1965 by Roche as a specific sedative-hypnotic drug. At that time it was already well known that diazepam mar-... 

Sedatives and Hypnotics Additional reports have appeared describing successful clinical use of nitrazepam. Mogadon ,... 

Several nitro groups in one molecule can make it quite unstable and even explosive. Three nitro groups give the most famous explosive of all, trinitrotoluene (TNT), its kick. However, functional groups refuse to be stereotyped. Nitrazepam also contains a nitro group, but this compound is marketed as Mogadon , the sleeping pill. 

Determination of Nitrazepam (Mogadon) in Plasma by Electron Capture Gas-Liquid Chromatography J. Chromatogr. 70(l) 45-52 (1972) CA 77 121961n... 

A family of drugs which are widely prescribed as tranquilizers and sleeping pills. Examples include diazepam (Valium), nitrazepam (Mogadon) and chlordiazepoxide (Librium). They are frequently taken in suicide attempts and can be detected in biological fluids by a number of techniques including examination of their absorption spectra following extraction. Diazo-tization reactions can also be used for their detection. 

Anti-anxiety drugs. The most used of the anxiolytics are the benzodiazepines which not only relieve anxiety, and relax skeletal muscle, but can suppress convulsions, all accomplished apparently by augmenting the inhibitory transmission effected by gamma-aminobutyric acid in the spinal cord (Choi, Farb, and Fischbach, 1977). Discovered in 1933, the benzodiazepines gained clinical acceptance about 1965 (Zbinden and Randall, 1967). The first used member was chlordiazepoxide ( Librium ) followed by the simpler, but more potent, diazepam (/J.//) ( Valium ). Some think that diazepam is a pro-drug for oxazepam ( Serax ) which is a N-demethylated and 3-hydroxylated metabolic product, and is frequently prescribed as such. Related benzodiazepines such as nitrazepam ( Mogadon ) and flurazepam are much used as hypnotics in the place of barbiturates. 

---