Modular synthesis

Modular Synthesis of a Mixed One-Bead - One-Selector Library... 

M. Ortega-Munoz, F. Perez-Balderas, J. Morales-Sanfrutos, F. Hemandez-Mateo, J. Isac-Garcia, and F. Santoyo-Gonzalez, Click multivalent heterogeneous neoglycoconjugates—Modular synthesis and evaluation of their binding affinities, Ear. J. Org. Chem., 2009 (2009) 2454-2473. 

Chen, G. Y., Lean, J. T., Alcala, M., Mallouk, T. E., Modular synthesis of -acceptor cyclophanes derived from... 

Figure 7.2 A schematic representation of a modular synthesis.54 (Reprinted in part with permission from M. Kawano et al., J. Am. Chem. Soc. 2007, 129, 15418-15419. Copyright 2007 American Chemical Society.)...

The examples discussed in this paper demonstrate that Pd-catalyzed coupling reactions can be successfully utilized in the convergent (modular) synthesis of vitamin D-active compounds. The new synthetic routes open an efficient and highly selective access to a variety of vitamin D analogs. While reliable methods exist today for the construction of the triene system and for the synthesis of the ring A precursors, the search for efficient total synthetic approaches to the CD building blocks still remain a challenging task for the future. 

An elegant modular synthesis of the 52 scaffold originates from methionine, which is transformed to isothiocyanate 54 by standard operations (Scheme 14) [31]. Condensation with an appropriate 1,3-diamine, here 55 derived from aspartate, is followed by exhaustive S-methylation inducing a smooth double ring closure. After deproteetion, guanidine 58 was isolated in gratifying 85 % yield. 

Figure 3.25 Modular synthesis of oxazoline functionalised NHC without linker group.

Based on the application of three iterative halogenation/cross-coupling reaction sequences Handy et al. developed a modular synthesis of the lamellarin G trimethyl ether <04JOC0000>. 

Wong JC, Sternson SM, Louca JB, ffong R, Schreiber SL. Modular synthesis and preliminary biological evaluation of stereochemi-cally diverse 1,3-dioxanes. Chem. Biol. 2004 11 1279-1291. 

Wong, J. C., Sternson, S. M., Louca, J. B., Hong, R., Schreiber, S. L. (2004). Modular synthesis and preliminary biological evaluation of stereochemically diverse... 

Scheme 6 Modular synthesis of SerPHOX and ThrePHOX ligands...

In more recent times, the field has increasingly focused on topics where molecular materials have an advantage over continuous-lattice solids. Such studies can exploit the modular synthesis of molecular materials, whereby different molecules with differing functions can be combined to form a hybrid material with interacting magnetic and/or conducting and/ or optical properties. This is leading to new fields such as molecular spintronics, multifunctional and switchable materials where... 

Orgueira HA, Bartolozzi A, Schell P, Litjens R, Palmacci ER, Seeberger PH. Modular synthesis of heparin oligosaccharides. Chem Eur J 2003 9 140-169. 

The synthesis of this simplified macrolactonic fragment of mycolactone A/B in hand, we next turned our attention to the development of a modular synthesis of the Cl -C16 southern fragment of mycolactone A/B. 

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