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Modified Reaction Conditions

A number of variations in reaction conditions have been explored. Indole and 1-methylindole can be condensed with formaldehyde and secondary amines in the presence of alumina with microwave heating [302]. [Pg.90]

Preformed iminium hydrochloride salts derived from benzaldehyde or isobutyr-aldehyde give good yields from indole and its 1 -methyl or 1 -benzyl derivatives [303]. [Pg.90]

Preformed imines of te-C2V-diarylimines react to give primary amines (60-80% yield), accompanied by small amounts of aryl-h/s-(indol-3-yl)methanes, in the presence of Dy(OTf)3 or other lanthanide salts [304]. [Pg.90]

The imine preformed from benzylamine and ethyl glyoxylate alkylates indole, its 1-, and 2-methyl analogs and other derivatives in the presence of catalytic Yb (OTf 3 [305]. [Pg.90]

W-Deprotonated indole anions give the 1-substituted indoles with these reagents [307]. [Pg.91]


Anilines react with ct-haloacetophenones to give 2-arylindoles. In a typical procedure an W-phenacylaniline is heated with a tw o-fold excess of the aniline hydrobromide to 200-250°C[1]. The mechanism of the reaction was the subject of considerable investigation in the 1940s[2]. A crucial aspect of the reaction seems to be the formation of an imine of the acetophenone which can isomerize to an aldimine intermediate. This intermediate apparently undergoes cyclization more rapidly (path bl -> b2) than its precursor (Scheme 7.3). Only with very reactive rings, e.g, 3,5-dimethoxyaniline, has the alternative cydiz-ation (path al a2) to a 3-arylindole been observed and then only under modified reaction conditions[3],... [Pg.77]

The reaction is of wide scope (R = alkyl, aryl) however the substrate molecule should not contain other functional groups that can react with diazomethane. With unsaturated acyl halides the yield can be poor, but may be improved by modified reaction conditions. ... [Pg.18]

The story of the ozone hole illustrates how important it is to learn the molecular details of chemical reactions. Some chemists use information about how reactions occur to design and synthesize useful new compounds. Others explore how to modify reaction conditions to minimize the cost of producing industrial chemicals. This chapter explores how chemical reactions occur at the molecular level. We show how to describe a reaction from the molecular perspective, introduce the basic principles that govern these processes, and describe some experimental methods used to study chemical reactions. [Pg.1047]

Several modified reaction conditions have been developed. One involves addition of silver salts, which activate the halide toward displacement.134 Use of sodium bicarbonate or sodium carbonate in the presence of a phase transfer catalyst permits Reactions involving especially mild conditions to be used for many systems.135 Tetraalkylammonium salts... [Pg.718]

The oxaspirocyclization was applied to the synthesis of theaspirone and vitispirane (equations 26 and 27)59. Under slightly modified reaction conditions where water is employed as the major solvent, palladium-catalyzed 1,4-oxidation of 64 afforded 65. Alcohol 65 was oxidized to theaspirone, which was obtained as a 1 1 isomeric mixture of cis and trans isomers. When the analogous reaction was performed at a lower pH by the use of trifluoroacetic acid, vitispirane was formed in high yield, again as a 1 1 isomeric mixture of stereoisomers. [Pg.675]

A number of modified reaction conditions have been developed. One involves addition of silver salts, which activate the halide toward displacement.94 Use of sodium bicarbonate or sodium carbonate in the presence of a phase-transfer catalyst permits especially mild conditions to be used for many systems.95 Tetraalkylammonium salts often accelerate reaction.96 Solid-phase catalysts in which the palladium is complexed by polymer-bound phosphine groups have also been developed.97 Aryl chlorides are not very reactive under normal Heck reaction conditions, but reaction can be achieved by inclusion of triphenylphosphonium salts with Pd(OAc)2 or PdCl2 as the catalyst.98... [Pg.505]

The platelet thickness can be adjusted to produce interference colors by modifying reaction conditions. When aligned with its plane orthogonal to the incident light, the platelet crystal behaves as a thin, solid, optical film (see Fig. 72) with two phase-shifted reflections from the upper and lower crystal planes (the phase boundaries). [Pg.217]

S. Gerisch, G. Ullmann, K. Stubenrauch, and H.-D. Jakubke, Enzymatic peptide synthesis in frozen aqueous systems influence of modified reaction conditions on the peptide yield, Biol. Chem. Hoppe Seyler, 1994, 375, 825-828. [Pg.370]

The above example (Schemes 2.9 and 2.10) illustrates a potentially general procedure (i) identify unexpected products (ii) consider mechanistic explanations (iii) modify reaction conditions (in this case using catalysts or inhibitors) to optimise the yield of desired products, and to test mechanistic deductions. Additional and more direct supporting evidence for radical intermediates is given in Chapter 10. [Pg.29]

Interestingly, however, another comparative study [24] revealed the capacity of other amines related to L-proline (S)-27 to function as organocatalysts in the Mannich reaction under modified reaction conditions [24]. As shown for a model reaction using preformed imines derived from o-anisidine, the thiazolidine carboxylic... [Pg.99]

Quinone monoacetal, which is obtained by careful hydrolysis of quinone diacetal, can also be prepared directly y anodic oxidation under modified reaction conditions. ... [Pg.800]

Deamination is the most commonly performed reaction of steroid Mannich bases. It is usually carried out by heating the base in the presence of acetic acid/acctic anhydride, - by column chromatography on silica gel, by heat decomposition of the corresponding hydrochloride or iodomethylate, or under suitably modified reaction conditions leading directly to the unsaturated final pnxluct starting from the usual Mannich reactants (Chap. II, A.2). [Pg.104]

Druey et have performed reactions of 4-methyl-3,6-dichloro-pyridazine with ammonia and other nucleophiles, but did not establish their structures. Later studies revealed that treatment of the mentioned pyridazine with anhydrous ammonia in methanol at 120° afforded a mixture of aminochloro-4-methylpyridazines in the ratio of about 1 10, the isomer 73a (X = NH2, R = Me) predominating. Also modified reaction conditions have led to a mixture of both isomers, where the isomer 73a was prevailing, and when di-methylamine has been used only isomer 73a (R=Me, X = NMe2) was isolated. From the reaction with hydrazine hydrate the isomer 74a (R=Me, X = NHNH2) is claimed to be the main product. [Pg.255]

The resulting platelets are less than 0.05 pm thick and show hexagonal dimensions of about 20 pm, yielding an aspect ratio of >200. Because of their high refractive index of 2.0 and their even surface, they exhibit a very strong luster. If the thickness of the platelets is increased by slightly modified reaction conditions, interference colors can be obtained [5.122, 5.123, 5.128, 5.130]. [Pg.236]

The use of a range of modified reaction conditions including the use of protic acids or conventional and nonconventional Lewis acid catalysts, pressure-promoted reaction conditions, - cation-radical catalysts, and dry-state adsorption reaction conditions has been employed to accelerate the 4it participation of sensitive heterodienes in thermally slow or problematic Diels-Alder reactions. The former two techniques have proven useful for promoting the typically poor reactions of simple, unactivated 1-oxa-1,3-butadienes or acyclic azadienes. [Pg.453]

Recently, some modified reaction conditions have been proposed to improve yields, particularly for aromatic carboxylic acids. A phosphonium anhydride reagent (11) made from triphenylphosphine oxide and triflic anhydride appears to induce reaction at low temperatures in common solvents giving high yields of 2-arylbenzi midazoles in 30-60 min at room temperature (Scheme 3.1.12) [78]. [Pg.76]

Various authors have reported obtaining pavinanes from 1,2-dihydroiso-quinolines in better yields, using modified reaction conditions. Walsh and Lyle, for example, added a solution of 35 in chloroform to a mixture of chloroform and 70% aqueous perchloric acid. After stirring for 72 hr at room temperature, the unsymmetrically substituted pavinane (36) was obtained in... [Pg.110]


See other pages where Modified Reaction Conditions is mentioned: [Pg.625]    [Pg.705]    [Pg.345]    [Pg.720]    [Pg.50]    [Pg.128]    [Pg.213]    [Pg.82]    [Pg.377]    [Pg.475]    [Pg.330]    [Pg.377]    [Pg.475]    [Pg.616]    [Pg.244]    [Pg.29]    [Pg.183]    [Pg.603]    [Pg.57]    [Pg.11]    [Pg.173]    [Pg.219]    [Pg.499]    [Pg.336]    [Pg.107]    [Pg.336]    [Pg.404]    [Pg.496]    [Pg.376]    [Pg.180]   


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Modified reaction

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