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Model protein machines

Synthetic Model Protein Machines Emulate Energy Conversions of Photosynthesis, Respiration, and Motion... [Pg.48]

Synthetic Model Protein Machines Pump Protons on Reduction... [Pg.48]

Synthetic Elastic-contractile Model Protein Machines to Energize Phosphates... [Pg.49]

Progression to Biology s Machines from Model Protein Machines... [Pg.50]

Finally, the electron microscope will become the dominant instrument for studying protein machines in vitro and in situ. Tomographic methods applied to single cells and molecules combined with automated reconstruction methods will generate models of protein-based structures that cannot be determined by x-ray crystallography. High resolution three-dimensional models of molecules in cells will help explain the intricate biochemical interactions among proteins. [Pg.193]

The outline of this chapter is as follows. The second section introduces a number of important supervised learning problems and illustrates how a biomolec-ular application can be cast in each problem formulation. Specifically, modeling protein-DNA interactions serves as the example for each of these formulations. The third section summarizes recent applications of machine learning to biomolec-ular modeling. The final section discusses current trends and future directions of machine learning applications to biomolecular modeling. [Pg.42]

Analogy Between Fully Charged Carboxylate (-COO ) State of Model Proteins and the ATP -bound State of Protein-based Machines... [Pg.10]

These results of 18 years ago, demonstrating the capacity of de wovo-designed model protein-based machines for the conversion of chemical energy into mechanical work, remain unex-... [Pg.27]

What can be demonstrated with model proteins functioning as contractile molecular machines is that two of the most effective means of lowering the temperature of an inverse temperatine transition to drive contraction are positively charged calcium ions (Ca ) binding at paired negatively charged carboxylates (COO ) to decrease net charge... [Pg.46]

Figure 5.2. The four phase transitions of the model protein (GVGVP)2si in water over the temperature range from -20 to 120°C. The familiar transition of the melting of ice and the vaporization of water are shown with the relative magnitudes of the heats of these transitions to those of protein heat denaturation and to the innocuous looking inverse temperature transition near 30°C that we believe to be the basis of the function of protein-based machines of Life. See text for discussion. Figure 5.2. The four phase transitions of the model protein (GVGVP)2si in water over the temperature range from -20 to 120°C. The familiar transition of the melting of ice and the vaporization of water are shown with the relative magnitudes of the heats of these transitions to those of protein heat denaturation and to the innocuous looking inverse temperature transition near 30°C that we believe to be the basis of the function of protein-based machines of Life. See text for discussion.

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Elastic-contractile model protein machines

Machine model

Model protein

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Model protein machines synthetic

Motion model protein machines

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Protein-based machines model

Protons model protein machines

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