Mobile vessels

Pipeless plants are an alternative to the traditional recipe-driven multipurpose batch plants with fixed piping between the units. In this production concept, the batches of material are moved around between stationary processing stations in mobile vessels. The processing steps are performed at different single purpose or multipurpose stationary units but the material remains in the same vessel throughout the production process. The transportation of the mobile vessels can be realized by a transportation system that is fixed to the vessels or by automated guided vehicles (AGV) that pick up the vessels only to perform a transfer order [1]. 

The transport of products or intermediates in mobile vessels enables a quick change of the priorities among the orders and the bypassing of stations that are temporarily unavailable by parking or redirecting of vessels. 

On the other hand, in comparison to traditional recipe-driven multipurpose batch plants, new technical requirements arise from the use of mobile units. An important pre-requisite for a safe and automatic production are reliable docking systems that provide failure-free connections between the mobile vessels and the stationary processing stations. In the docking process of the mobile vessels the connection of pipes, of electric power and of signal processing equipment is necessary. The vessels therefore must be placed accurately. If vessels of different size are used, the connections must be flexible enough to cope with these. 

The pipeless plant concept leads to 20% shorter processing times for batch sizes between 200 and 500 kg, what clearly reduces the manufacturing costs of the products. By the distribution of the technical functions on several stations, the transport of the intermediate products in mobile vessels and the cleaning of the vessels in separate cleaning stations, the utilization of the stations rises and in parallel the productivity of the plant is increased. 

Step 3. The compounded bulk solution is prefiltered through a 0.2-p,m sterile filter to a sterile mobile vessel, which is then transferred to the... 

Product filling Ambient temperature in a sterile mobile vessel hours from start of... 

The compounded product is prefiltered into a sterile mobile vessel in the compounding area and transported to the solution holding room for final filtration. 

Process and equipment validation certification guideline Hot air sterilization tunnel certification/validation guideline Steam sterilization certification/validation guideline Validation and certification of hot air sterilization tunnel Validation and certification of SIP preparation/mobile vessel Validation/revalidation of sterilization cycles in sterilizer by Kaye validator... 

All parameters and test results for SIP cycle were found in compliance. The SIP cycle of the mobile vessel is considered requalified and approved for regular sterilization. 

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