Mixtures high-speed analysis

It is seen from Figure 15 that the analysis time ranges from about 10,000 seconds (a little less than 3 hr) to about 30 milliseconds. The latter, high speed separation, is achieved on a column about 2 mm long, 12 microns in diameter, operated at a gas velocity of about 800 cm/second. Such speed of elution for a multicomponent mixture is of the same order as that of a scanning mass spectrometer. 

Direct pyrolysis in the ion source of a mass spectrometer (QMS) was used to analyse PE/(dicumylperoxide, Santonox R) and PVC/DIOP [259]. In-source PyMS is an analytical tool for fast analysis of flame retardants in unknown mixtures of polymers [223, 265], Heeren and Boon [224] used in-source filament pyrolysis FTMS for high-speed, broadband screening of additives in polymeric household appliances. 

CPC Spin Column/ESI-MS Ease of Use, Mixture Analysis, High Speed, Reliability, Uncoupling of CPC from ESI-MS and HPLC ESI-MS... 

Arataev, V. B. Burrill, P. H. McNitt, K. L. Schmitz, D. A. Enke, C. G. Holland, J. F. High-Speed GC/MS Analysis of Complex Mixtures Using Time-of-Flight Mass Spectrometry with Time-Array Detection. Poster TP 186 presented at the 42nd ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, Illinois, May 29 - June 3, 1994. 

MALDI and ESI represent the predominant ionization techniques in mass spectrometry-based proteomics, as recognized by the Nobel Prize in chemistry in 2002. MALDI is mainly used to volatize and ionize simple polypeptide samples for mass spectrometric (MS) analysis at high speed. The analysis of more complex peptide mixtures is usually conducted via ESI mass spectrometry (ESI MS) coupled online with a high-pressure liquid chromatography (HPLC) system to concentrate and separate peptides prior to MS analysis. 

Analysis of the C z and C e olefin mixtures by gas chromatography and/or NMR indicated that in both cases the internal isomers were the predominant product. With all the alkylaluminum coinitiators the ratio of internal to terminal olefin was 3 1. Product characterization data are shown in Table 1. Number average molecular weights of polyisobutylenes were determined using a Hewlett-Packard 503 high speed membrane osmometer at 37° C and toluene solvent. Intrinsic viscosities were obtained with a Ubbelohde capillary viscometer at 30° C in cyclohexane solvent. The viscosity average molecular weights were calculated... 

In this study, we used matrix-assisted laser desorption ionization /Mass Spectrometry (MALDI/MS) to identify the peptides released from gastric parietal cell microsomes. MALDI, because of its sensitivity and relative tolerance to the presence of salts and buffers was examined for the analysis of unfractionated proteolytic digests (9, 10). MALDI with post-source decay (PSD) analysis was used to obtain sequence information on peptides even in crude digestion mixtures. Our strategy (Figure 1) consisted of proteolysis of intact vesicles, centrifugation at high speeds to separate membrane bound and soluble fractions and analysis of the mixture of released peptides by MALDI/MS. In addition, to increase the... 

The main method of analysis of monoterpenoids in essential oils is a capillary gas chromatography. Due to the high volatility of monoterpenoids and the high speed and efficiency of the capillary gas-chromatography it is applied nowadays as the most universal method for a qualitative and quantitative analysis of monoterpenoids mixtures. 

The fast pace and highly interdisciplinary nature of drug discovery research further requires that these trace/mixture methods accommodate high-throughput analysis formats. Thus, there exists a balance between simplicity and complexity to provide methods that generate data and inspire confidence while maintaining speed. 

---