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Leukemia mixed lineage

MDS, myelodysplastic syndrome MLL, mixed lineage leukemia MPD, myeloproliferative disease PML, promyelocytic leukemia RAR, retinoic acid receptor-a. [Pg.2488]

HLA human leukocyte antigen HSCT hematopoietic stem cell transplantation hyper-CVAD high-dose methotrexate and cytarabine alternating with fractionated cyclophosphamide plus vincristine, doxorubicin, and dexamethasone IBMTR International Bone Marrow Transplant Registry IL-2 interleukin-2 MDS myelodysplastic syndrome MLL mixed lineage leukemia MUD matched unrelated donor NCCN National Comprehensive Cancer Network NST nonmyeloablative stem cell transplant OS overall survival Ph+ Philadelphia chromosome PML promyelocytic leukemia (gene)... [Pg.2507]

GlaxoSmithKline reported on a related compound, I-BET762 [278, 279]. A compound from a different series, I-BET151, has shown efficacy against mixed lineage leukemia (MLL) cell lines in vitro and in vivo [280]. [Pg.41]

A disturbing complication of etoposide therapy is the development of an unusual form of acute nonlymphocytic leukemia with a translocation in chromosome 11 at llq23. This locus contains the MLL or mixed-lineage leukemia gene that regulates the proliferation of pluripotent stem cells. [Pg.890]

Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ. Acute mixed lineage leukemia t(4 ll)(q21 q23) generates an MLL0-AF4 fusion product. Proc Natl Acad Sci USA. 1999 90 7884-8. [Pg.685]

See other pages where Leukemia mixed lineage is mentioned: [Pg.42]    [Pg.258]    [Pg.363]    [Pg.406]    [Pg.463]    [Pg.7]    [Pg.256]    [Pg.267]    [Pg.198]    [Pg.25]    [Pg.1565]    [Pg.3461]    [Pg.2494]    [Pg.259]    [Pg.174]    [Pg.167]    [Pg.245]    [Pg.354]    [Pg.579]    [Pg.340]   
See also in sourсe #XX -- [ Pg.254 ]

See also in sourсe #XX -- [ Pg.167 ]



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