Mitomycin gastric cancer

Mitomycin C Lung cancer. Various disseminated refractory malignandes. Gastric cancer... 

UFT was studied in combination with radiation therapy in patients with locally advanced, inoperable gastric carcinoma. Tsukiyama et al. (66) evaluated combined modality therapy (CMT) consisting of UFT and mitomycin-C administered together with radiation therapy, and reported local control in 70% of patients with advanced inoperable gastric cancer. 

Koga, S., Hamazoe, R., Maeta, M., Shimizu, N, Murakami, A., and Wakatsuki,T. (1988), Prophylactic therapy for peritoneal recurrence of gastric cancer by continuous hyperthermic peritoneal perfusion with mitomycin C, Cancer, 61,232. 

Hartmann JT, Quietzsch D, Daikeler T, Kollmannsberger C, Mayer F, Kanz L, Bokemeyer C. Mitomycin C continuous infusion as salvage chemotherapy in pretreated patients with advanced gastric cancer. Anticancer Drugs 1999 10(8) 729-33. 

Mitomycin C (Mutamycin) Gastric cancer, breast cancer bladder cancer (instillation) esophageal cancer cervical cancer colorectal cancer NSCLC... 

Inoue Y et al. (1994) Hypervascular liver metastases of gastric cancer completely responding to transcatheter oily chemoembolization using epirubicin hydrochloride, mitomycin C and lipiodol. Gan To Kagaku Ryoho 21 1665-1667... 

Streptomyces caespitosus produces several mitomycins, antibiotics that show an excellent antitumor activity but of limited utility because of their toxicity. The only substance acceptable for human use is mitomycin C, approved by FDA in 1974. Mitomycin C acts by forming covalent bridges across two opposite DNA strands, causing a rapid cell death (Tomasz 1995). In contrast to most antitumor agents, it is also active against the hypoxic cells in the core of solid tumors and therefore is indicated for the treatment of specific type of neoplasms such as gastric, colorectal, and lung cancer. 

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