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Mitochondria in ageing

Pang, C.Y., Ma, Y.S. and Wei, YU. (2008) MtDNA mutations, functional decline and turnover of mitochondria in aging. Frontiers in Bioscience a Journal and Virtual Library, 13, 3661-3675. [Pg.381]

As aptly put by Wallace in a comprehensive review of mitochondria in aging, degenerative diseases, and cancer [1], "ROS damage to the mitochondria, mtDNA, and host cells must be one of the most important entropic factors in determining age-related cellular decline."... [Pg.83]

Beal ME (2005) Mitochondria take center stage in aging and neurodengeration. Ann Neurol 58 495—505. [Pg.398]

R. B. Sewell, N. D. Yeomans, D. J. Morgan, and R. A. Smallwood, Hepatic Kupffer cell function the efficiency of uptake and intracellular degradation of C labeled mitochondria is reduced in aged rats. Mech Ageing Dev 73(3) 157-168 (1994). [Pg.1030]

These results suggest that ROS generation is greater in and around mitochondria and peroxisomes in young rats than in aged animals and that caloric restriction suppresses ROS generation in mitochondria but not in peroxisomes in both animal groups. [Pg.298]

A similar connection between a decrease in CL levels and the age-linked decline of rat heart mitochondrial cytochrome c oxidase activity was demonstrated. Treatment of heart mitochondria from aged rats with CL-liposomes restored their lower cytochrome c oxidase activity to the level of young control rats (Paradies et al., 1997b). Again, no restoration of activity was found after treatment with other phospholipids or with peroxidized CL. CL level in heart mitochondria was shown to be regulated by thyroid hormone (Mutter et al.,... [Pg.223]

Mitochondial diseases. Mitochondria contain DNA and can reproduce by replicating their DNA and then dividing in half. Although nuclear DNA encodes most of the enzymes found in mitochondria, mitochondrial DNA encodes some of the subunits of the electron transport chain proteins and ATP synthase. Mutations in mitochondrial DNA result in a number of genetic diseases that affect skeletal muscle, neuronal, and renal tissues. They are implicated in aging. [Pg.171]

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See also in sourсe #XX -- [ Pg.234 ]



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