Mitchell. Peter

Mitchell, Peter. D. (1920-1992). A British biochemist who was the recipient of the Nobel Prize for chemistry in 1978 for his work on studies of cellular energy transfer. A graduate of Cambridge and recipient of many awards, he was the Director of Research, Glynn Research Institute. 

Mitchell/ Peter Dennis (1920-92) English biochemist who revolutionized thought on the process of oxidative phosphorylation in which adenosine triphosphate (ATP) is regenerated from adenosine diphosphate (ADP) and phosphate. Breakdown of ATP to ADP releases large amounts of energy for cell functions from the phosphate bonds. MitcheU proposed that electron transport formed a proton gradient across the mitochondrial membrane that directly brought about the synthesis of ATP from ADP. He was awarded the 1978 Nobel Prize in chemistry. 

In 1961, Peter Mitchell, a British biochemist, proposed that the energy stored in a proton gradient across the inner mitochondrial membrane by electron transport drives the synthesis of ATP in cells. The proposal became known as... 

Peter Mitchell s chemiosmotic hypothesis revolutionized our thinking about the energy coupling that drives ATP synthesis by means of an electrochemical gradient. How much energy is stored in this electrochemical gradient For the transmembrane flow of protons across the inner membrane (from inside [matrix] to outside), we could write... 

In 1961, Peter Mitchell proposed a novel coupling mechanism involving a proton gradient across the inner mitochondrial membrane. In Mitchell s chemiosmotic hypothesis, protons are driven across the membrane from the matrix to the intermembrane... 

Peter Mitchell Great Britain chemiosmotic theory... 

Kravitz, Richard L, Ronald M. Epstein, Mitchell D. Feldman, Carol E. Franz, Rahman Azari, Michael S. Wilkes, Ladson Hinton, and Peter Franks. 2005. Influence of Patients Requests for Direct-to-Consumer Advertised Antidepressants A Randomized Controlled Trial. /owmaZ o/i/ieAmerican Medica/Associaiion 293( 16) 1995-2002. 

Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med 1991 324 781-8. 

Karen Mitchell, James L.Fordf, David J.Armstrong, Peter N.C.lliott and... 

The chemiosmotic model, proposed by Peter Mitchell, is the paradigm for this mechanism. According to the model Peter Mltchel1,... 

Peter Mitchell Chemistry Biological energy transfer... 

Figure 18-9 Proposed routes of electron transfer in mitochondrial complex III according to Peter Mitchell s Q cycle. Ubiquinone (Q) is reduced to QH2 by complex I (left side of diagram) using two H+ taken up from the matrix (leaving negative charges on the inner membrane surface). After diffusing across the bilayer (dashed line) the QH2 is oxidized in the two steps with release of the two protons per QH2...

---