Misoprostol release

Misoprostol (B) is a semisynthetic prostaglandin derivative with greater stability than natural prostaglandin, permitting absorption after oral administration. like locally released prostaglandins, it promotes mucus production and inhibits acid secretion. Additional systemic effects (frequent diarrhea risk of precipitating contractions of the Liillmann, Color Atlas of Pharmacology (... 

Searle GD. Important drug warning concerning unapproved use of intravaginal or oral misoprostol in pregnant women for induction of labor or abortion. Media Release 23 August 2000. 

Oral 20 mg delayed-release tablets Mucosal Protective Agents Misoprostol (Cytotec)... 

In a recent study, gel-formers have shown to be effective carriers for the controlled release of misoprostol in a newly developed animal model for studying induced cervical ripening. 

A number of strategies are used to reduce the risk of NSAID-related ulcers and GI complications. Strategies aimed at reducing the topical irritant effects of nonselective NSAIDs—prodrngs, slow-release formulations, and enteric-coated prodncts—do not prevent nlcers or GI complications snch as bleeding or perforation. Medical cotherapy with misoprostol or a PPI decreases the risk of nlcers and GI complications in high-risk patients (see Table 33-3). ... 

Yes. Misoprostol does not affect histamine-mediated release. Therefore, the two drugs would have a synergistic action. 

Misoprostol (Cytotec) Prostaglandin E analog which increases HCO3 and mucin release. Also reduces acid secretion. Prevention of ulcers caused by aspirin and other NSAIDS. Abortion (uterine contraction), diarrhea, abdominal pain, nausea, flatulance. 

PEG-based copolyesters possess the ability to serve as absorbable controlled release carriers for a whole host of bioactive agents. The ability to provide a means of local therapy with systemically toxic agents directly at the site of interest has heightened awareness of these PEG-based systems. In addition, since these copolymers are absorbable, they allow for local drug delivery without the inherent risks associated with permanent foreign bodies. Some applications of the PEG-based systems include, but are not limited to, antibiotic formulations for osteomyelitis, controlled release of vaccines, intra-vaginal delivery of misoprostol, periodontal application of antibiotics, and intraocular drug delivery. 

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