Minocycline vestibular toxicity

Tetracyclines are used as alternative dnigs in a variety of circumstances when the patient is unable to take the dnig of choice, eg, in patients allergic to penicillin (88,89). Tetracyclines are widely known to cause staining of teeth (and are therefore contra-indicated in children developing permanent teeth), photosensitivity, and, in the case of minocycline, vestibular toxicity. Details of these adverse effects and others associated with administration of tetracyclines have been comprehensively reviewed (96—101). 

Minocycline Tablets, capsules 50, 75, 1 00 mg 50 mg twice daily or 100 mg once daily Maintenance dose 50 mg daily Gl upset, phototoxicity, drug and food interactions, vestibular toxicity, skin discoloration... 

Minocycline Oral longer half-life (16 h) so dosed twice daily frequently causes reversible vestibular toxicity... 

Vestibular toxicity appears to be unique to minocycline. Lightheadedness, loss of balance, dizziness, nausea, and tinnitus beginning 2 to 3 days after starting therapy can occur in up to 70% of patients. Although these side effects are usually reversible after discontinuing the drug, they have severely limited the use of minocycline. 

Vestibular toxicity Dose-dependent reversible dizziness and vertigo have been reported with doxycycUne and minocycline. 

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