Minimum Information About

Abbreviation Bp, nucleotide base pairs cDNA, complementary DNA ChIP, chromatin Immunoprecipi-tation Cy5, cyanine 5-dCTP Cy3, cyanine 3-dCTP ESTs, expressed sequence tags FDR, false discovery rate MIAME, minimum information about a microarray experiment mRNA, RNA, messenger NIA, National Institutes of Aging RFUs, relative fluorescence units RT-PCR, reverse transcriptase polymerase chain reaction SAGE, serial analysis of gene expression SAM, significance analysis of microarrays... 

Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, et al. 2001. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nature Genetics 29 365. 

Figure 1.16 Critical issues facing DNA microarrays and protein microarrays. MIAME = minimum information about a microarray experiment, checklist endorsement as of October 14, 2002. RCA = rolling circle amplification. RLS = resonance light scattering.

To make full use of microarray data it is necessary that data of published microarray experiments be made available to other researchers for comparison purposes. To this end, the Minimum Information About a Microarray Experiment (MIAME) (31) guidelines have been developed at the European Bioinformatics Institute (EBI). This standard describes the minimum information required to ensure that microarray data can be easily interpreted, and that results derived from its analysis can be independently verified. 

Representative samples of each lot will be collected for testing in accordance with the established procedure. The number of containers to sample and the sample size should be based upon appropriate criteria as required by 211.84 (3) (e.g., raw material variability, confidence levels, degree of precision desired, past quality history of the supplier, and the quantity needed for analysis). Sample containers should be properly labeled. The label should include, at minimum, information about the sample name, manufacturer name, sample size, and date and hour of sampling. Raw material containers selected for sampling should be opened, sampled, and resealed in a manner that prevents contamination of their contents and of other raw materials. 

The Minimum Information About a Microarray Experiment Standard... 

The essential merit of pinch-point analysis is that makes possible the identification of key targets for energy saving with minimum information about the performance of heat-exchange equipment The key results of are ... 

Wiemann, S. et al. 2007. MIACA minimum information about a cellular assay, and the cellular assay object model. http //www.nature.com/nbt/consult/pdf/Wiemann.pdf. 

MIAME Minimum information about a microarray experiment... 

MI APE (Minimum Information about a Proteomics Experiment) [250] http //psidev.sourceforge.net/... 

The Microarray Gene Expression Data Society created the MIAME (Minimum Information About a Microarray Experiment) standards for the description of microarray experiments and for the exchange of microarray data. 

Minimum Information About a Microarray Experiment (MIAME) for Toxicogenomics, European Bioinformatics Institute, National Center for Toxicogenomics, International... 

It is important that all the information that may be needed to interpret the results of a microarray experiment at a later date, and possibly to verify the experiment, is captured and recorded in the database. The microarray data annotations working-group of MGED has developed a list of requirements that have to be satisfied to meet these goals, called the Minimum Information About a Microarray Experiment (MIAME). 

The minimum information about a published microarray based gene expression experiment includes the following six parts ... 

Brazma, A., Hingamp, P., Quackenbush, J., Sherlock, G., Spellman, P., Stoeckert, C., Aach, J., Ansorge, W., Ball, C.A., Causton, H.C., et al. 2001. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 29 365-371. 

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