Milontin - Phensuximide

Millevit - Cyanocobalamin Milliderm - Hydrocortisone Milligynon - Norethindrone acetate Milontin - Phensuximide Miltaun - Meprobamate Miltown - Meprobamate Mllurit - Allopurinol... 

Gastrointestinal symptoms occur frequently with the administration of ethosuximide (Zarontin), methsux-imide (Celontin Kapseals), and phensuximide (Milontin Kapseals). Mental confusion and other personality changes, pruritus, urticaria, urinary frequency, weight loss, and hematologic changes may also be seen. 

Phensuximide, like ethosuximide, is an anticonvulsant drug used in minor forms of epilepsy. It is also prescribed under the name milontin. 

Drugs in this category include ethosuximide (Zaron-tin), methsuximide (Celontin), and phensuximide (Milontin). All three drugs are primary agents in the treatment of absence (petit mal) seizures, but ethosuximide is the most commonly prescribed. 

Phensuximide, USP. Some trophism toward antiabsence activity is attributed to the succinimide system. The -CHi- could be viewed as an a-alkyl branch condensed into the ring. Phensuximide. A(-melhyl-2-phenylsuccinimidc (Milontin), is used primarily against absence seizures, hut it has low potency and is relegated to secondary status. The... 

Three succinimides have proved useful in the control of absence seizures ethosuximide (proprietary name Zaron-tin), methsuximide (proprietary name Celontin), and phen-suximide (proprietary name Milontin). Ethosuximide is widely used and is reviewed elsewhere in this chapter. Methsuximide and phensuximide are less commonly used and monitored. 

Phensuximide. t-Methyt-3-phenyt-2,5-pyrroti-dinedione S-tnethyl-2-phinylsuccitiirnide JV-methyl-a-phenylsuccinimide Lifene Succitimal Milontin Miron tin. CmHmNC mol wt 189.21. C 69.82%, H 5.86%, N 7.40%, O 16.91%. rrepd by the action of methylamine on phenylsuc-cinic acid Miller, Long, J. Am, Chem. Soc. 73, 4895 (1951) U.S, pat. 2,643,258 <1953 to Parke, Davis). 

N-Me [86-34-0]. l-Methyl-3 phenyl-2,5-pyrrolidinedione, 9CL N Methyl-l-phenylsuccinimide. Phensuximide BAN, INN. Epimid. Lepsol. Lifene. Milontin. Milonton. Mirontin. Petimid. Succitimal. PM 334. Fensuximide C H N02 M 189.213 Anticonvulsant. Fine cryst. (EtOH). Mp 71-73°. 

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