Miller 1 Preparation

Otomize (Stafford-Miller) preparations Metasolon (Shionogi)... 

Premarin (Wyeth-Lederle) Hormestrin (Smith, Miller preparations and generic ... 

J.G. Purdon, J.G. Pagatto and R.K. Miller, Preparation, stability and quantitative analysis by gas chromatography and gas chromatography/electron impact mass spectrometry of fert.-butyldimethy-lsilyl derivatives of some alkylphosphonic and alkyl methylphosphonic acids, 7. Chromatogr., 475, 261-272 (1989). 

T. Beecroft and A.W. Miller, Preparation and Characterisation of Solid Catalysts , Repts. Progr. Appl. Chem. 55 (1970) 385. 

Glattfeld and Miller prepared the racemic acid, in accordance with the... 

S. J. Miller, Preparing a High Viscosity Index, Low Branch Index Dewaxed Base Stock, U.S. Patent 6,663,768. 

M. S. El-Aasser and C. M. Miller, Preparation of latexes using miniemulsions, in Polymeric Dispersions—Principles and Applications, J. M. Asua (Ed.), Kluwer, Dordrecht, 1997, pp. 109-126. 

Quinaldine (or 2-methylquinoline) can be prepared by the Doebner.Miller Synthesis, which in some respects is closely similar to the Skraup Synthesis (p. 297) but has some significant differences. 

To meet the needs of the advanced students, preparations have now been included to illustrate, for example, reduction by lithium aluminium hydride and by the Meerwein-Ponndorf-Verley method, oxidation by selenium dioxide and by periodate, the Michael, Hoesch, Leuckart and Doebner-Miller Reactions, the Knorr pyrrole and the Hantzsch collidine syntheses, various Free Radical reactions, the Pinacol-Pinacolone, Beckmann and Arbusov Rearrangements, and the Bart and the Meyer Reactions, together with many others. 

The cyclic carbonate of benzoin (4,5-diphenyl-l,3-dioxol-2-one, prepared from benzoin and phosgene) blocks both hydrogen atoms of primary amines after dehydration acid stable, easily crystallizable Sheehan oxazolinones are formed, which are also called Ox derivatives. The amine is quantitatively deblocked by catalytic hydrogenation in the presence of 1 equiv. of aqueous acid (J.C Sheehan, 1972, 1973 M.J. Miller, 1983). An intelligent application to syntheses of acid labile -lactams is given in the previous section (p. 161). 

W. T. Miller, "General Discussion of Chlorotriduoroetliylene Polymers," in C. Slesser and S. R. Scliram, eds.. Preparation, Properties and Technology of Fluorine andOrganicFluoro Compounds, McGraw-HiU Book Co., New York, 1951. 

W. E. Hatfield and J. H. Miller, Jr., eds., High-Temperature SuperconductingMaterials, Preparations, Properties, and Processing, Marcel Dekker, Inc., New... 

Table 9-51 fflves typical values of such factors for carbon steel installations taken from the data of D. R. Woods Financial Decision Making in the Process Industiy, Prentice Hall, Englewood Cliffs, NJ, 1975, p. 184). Auxiliaries and site preparation are given as factors of the delivered-equipment cost in Table 9-51, whereas C. A. Miller [Chem. 

Pilot-plant [Hyde, Miller, Packham, and Richards, J. Am. Water Works A.S.SOC., 69, 369 (1977)] and full-scale [Ward, Water Serv., 81, 499 (1977)] flotation in the preparation of potable water is described. 

Wipf and Miller have reported side-chain oxidation of 3-hydroxy amides with the Dess-Martin periodinane, followed by immediate cyclodehydration with triphenylphosphine-iodine, which provides a versatile extension of the Robinson-Gabriel method to substituted oxazoles. Application of this method was used to prepare the oxazole fragment 10 in 55% overall yield from 3-hydroxy amide 8. 

The preparation of 3-alkyl quinolines by traditional Skraup/Doebner-von Miller reaction typically results in very low yields. When ethylacrolein (9) is condensed with m-toluidine (8) under typical Skraup/Doebner-von Miller conditions, the yield of 10 is only 25%, compared to 65% with di-acetyl acetal 11. 

A number of dihydroquinolines have been prepared by treating aniline derivatives with acetone or mesityl oxide in the presence of iodine. In these cases aromatization to the fully unsaturated quinoline would require the loss of methane, a process known as the Riehm quinoline synthesis. Such Skraup/Doebner-von Miller-type reactions are often low yielding due to large amounts of competing polymerization. For example, aniline 37 reacts with mesityl oxide to give dihydroquinolines 39, albeit in low yield. ... 

Interestingly the Skraup/Doebner-von Miller reaction has been used to prepare a number of spiro-compounds. Aniline was reacted with enone 42 in the presence of iodine to yield dihydroquinoline 43 in acceptable yields. 

Malonic acid has been made by the hydrolysis of malononitrile with concentrated hydrochloric acid,2 by the hydration of carbon suboxide,3 and by the hydrolysis of cyanoacetic acid4 and its esters5 with potash. A method for the preparation of calcium malonate from chloroacetic acid and potassium cyanide is described by Fischer.6 Conrad7 liberated malonic acid from calcium malonate, so prepared, with oxalic acid. v. Miller,8 Grimaux and Tscherniak, and Bourgoin10 prepared malonic acid from chloroacetic acid and potassium cyanide, Petriev11 from... 

The preparation of this paper was supported by the Office of Naval Research under Contract Nonr-3809(00). The authors are grateful to W. J. Miller for permission to use his as yet unpublished data in Figures 3 and 4. 

A number of complexes of copper with 1,1-dithiolenes are known they are interesting, inasmuch as they form (1) polynuclear species, e.g., [Cu4(i-mnt)3]2 . Recently, a copper(III) complex of 1,1-dicarboeth-oxy-2-ethylenedithiolate (DED ) was prepared (375) by oxidation of aqueous solutions of K2[Cu(DED)2] with a 10-15% excess of Cu(II) or H202, and of (BzPh3P)2[Cu(DED)2] with I2. The possibility of this system as a model for the Cu "/Cu. system in n-galactose oxidase has been pointed out. Lewis and Miller (113) also prepared M[Cu(S2C CHN02)2] (M = Cu, or Zn) and Cu[Cu S2C C(CN)2 2], and found that they are effective insecticides. 

Nytol (Stafford-Miller) numerous combination preparations... 

Eerrocene (1) was the first sandwich complex to be discovered, thereby opening a wide and competitive field of organometallic chemistry. The formation of ferrocene was found at almost the same time in two independent studies on July 11, 1951, Miller, Tebboth, and Tremaine reported that on the passage of N2 and cyclopenta-diene over a freshly prepared mixture of reduced Ee (90%), alumina (8%), potassium oxide (1%), and molybdenum oxide (1%) at 300°C, yellow crystals identified as Cp2Ee (Eig. 1) were obtained [1]. Due to the low yields obtained (3 g starting from 650 g ferric nitrate), doubts remain as to whether Ee(0) was the... 

An interesting idea has been to prepare the photosensitive electrode on site having the liquid play the dual role of a medium for anodic film growth on a metal electrode and a potential-determining redox electrolyte in the electrochemical solar cell. Such integration of the preparation process with PEC realization was demonstrated initially by Miller and Heller [86], who showed that photosensitive sulfide layers could be grown on bismuth and cadmium electrodes in solutions of sodium polysulfide and then used in situ as photoanodes driving the... 

Miller DJ, Haneman D (1981) Preparation of stable efficient CdSe films for solar PEC cells. Sol Energy Mater 4 223-231... 

Miller, K.J. Anderholm, D.C. and Ames, M.M. Metabolic activation of the serotonergic neurotoxin para-chloroamphetamine to chemically reactive intermediates by hepatic and brain microsomal preparations. Biochem Pharmacon>5 mi- lA2, 1986. 

Because of the possibility that the herbicide alachlor could adulterate food if either poultry or livestock consumed contaminated materials, Lehotay and Miller evaluated three commercial immunoassays in milk and urine samples from a cow dosed with alachlor. They found that milk samples needed to be diluted with appropriate solvents (1 2, v/v) to eliminate the matrix effect. One assay kit (selected based on cost) was also evaluated for use with eggs and liver samples from chickens. Egg and liver samples were blended with acetonitrile, filtered, and diluted with water. Linear calibration curves prepared from fortified egg and liver samples were identical... 

Miller, L., Orihuela, C., Fronek, R., and Murphy, J., Preparative chromatographic resolution of enantiomers using polar organic solvents with polysaccharide chiral stationary phases,. Chromatogr. A, 865, 211, 1999. 

A detailed account of methods of AP specimen preparation has been given by Miller and Smith (1989) to which reference may be made if necessary. 

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