Milk fat globule membrane

Lipids are insoluble in water and an interfacial tension therefore exists between the phases when lipids are dispersed (emulsified) in water (or vice versa). This tension in toto is very large, considering the very large interfacial area in a typical emulsion (section 3.7). Owing to the interfacial tension, the oil and water phases would quickly coalesce and separate. However, coalescence (but not creaming) is prevented by the use of emulsifiers (surface active agents) which form a film around each fat globule (or each water 

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Lactadherin is a glycoprotein produced by mammary epithelial cells during lactation and associated with the milk fat globule membrane (Newburg et ah, 1998). Its concentration in milk peaks at 0.139 mg/ml immediately postpartum and declines thereafter (reviewed by Kvistgaard et ah, 2004). It has been reported to bind to human Rotavirus,... 

Schroten, H., Hanisch, F. G., Plogmann, R., Hacker, J., Uhlenbruck, G., Nobis-Bosch, R., and Wahn, V. (1992). Inhibition of adhesion of S-fimbriated Escherichia coli to buccal epithelial cells by human milk fat globule membrane components A novel aspect of the protective function of mucins in the nonimmunoglobulin fraction. Infect. Immun. 60,2893-2899. 

King, N. "The Milk Fat Globule Membrane", Comm. Agr. Bur., Farnham Royal, Bucks, England, 1955. 

Table 3.9 Gross composition of the milk fat globule membrane...

Table 3.10 Composition of bovine milk fat globule membranes...

Table 3.12 Enzymatic activities detected in bovine milk fat globule membrane preparations...

Figure 3.18 Schematic representation of a trilaminar cell membrane which is derived from the apical membrane of the mammary cell and forms the outer layer of the milk fat globule membrane following expression from the mammary cell, but which is more or less extensively lost on ageing. 1, phospholipid/glycolipid 2, protein 3, glycoprotein.

Anderson, M., Cawston, T. and Cheeseman, G. C. 1974. Molecular weight estimates of milk fat globule membrane protein-sodium dodecyl sulfate complexes by electrophoresis in gradient acrylamide gels. Biochem. J. 139, 653-660. 

Anderson, M. and Cheeseman, G. C. 1971. Some aspects of the chemical composition of the milk fat globule membrane during lactation. J. Dairy Res. 38, 409-417. 

Basch, J. J., Farrell, H. M. Jr. and Greenberg, R. 1976. Identification of the milk fat globule membrane proteins. I. Isolation and partial characterization of a glycoprotein B. Biochim. Biophys. Acta 448, 589-598. 

Jarasch, E. D., Bruder, G., Keenan, T. W. and Franke, W. W. 1977. Redox constituents in milk fat globule membranes and rough endoplasmic reticulum from lactating mammary gland. J. Cell Biol. 73, 223-241. 

Kanno, C., Shimizu, M. and Yamauchi, K. 1975. Isolation and physicochemical properties of a soluble glycoprotein fraction of milk fat globule membrane. Agr. Biol. Chem. 39, 1835-1842. 

King, N. 1955. The milk fat globule membrane. Technical Communication No. 2. Commonwealth Bureau of Dairy Science, Commonwealth Agriculture Bureau, Famham Royal, Bucks, England. 

Kobylka, D. and Carraway, K. L. 1972. Proteins and glycoproteins of the milk fat globule membrane. Biochim. Biophys, Acta 288, 282-295. 

Mather, I. H., Weber, K. and Keenan, T. W. 1977. Membranes of mammary gland. XII. Loosely associated proteins and compositional heterogeneity of bovine milk fat globule membrane. J. Dairy Sci. 60, 394-402. 

Nielson, C. S. and Bjerrum, 0. J. 1977. Crossed immunoelectrophoresis of bovine milk fat globule membrane protein solubilized with non-ionic detergent. Biochim. Biophys. Acta 466, 496-509. 

Bracco, U., Hidalgo, J. and Bohren, H. 1972. Lipid composition of the milk fat globule membrane of human and bovine milk. J. Dairy Sci. 55, 165-172. 

McPherson, A. V. and Kitchen, B. J. 1983. Review of the progress of dairy science The bovine milk fat globule membrane—its formation, composition, structure and behavior in milk and dairy products. J. Dairy Res. 50, 107-133. 

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