Midazolam Calcium-channel blockers

Anxiolytics clonazepam, diazepam, temazepam, triazolam, alprazolam, midazolam, buspirone Anticonvulsants ethosuximide, carbamazepine Calcium channel blockers diltiazem, felodipine, nifedipine, verapamil... [Pg.93]

Drugs that might be affected by lopinavir/ritonavir include ergot derivatives, oral contraceptives, antiarrhythmics, HMG-CoA reductase inhibitors, HIV protease inhibitors, atovaquone, calcium channel blockers, ketoconazole, itraconazole, pimozide, cisapride, clarithromycin, disulfiram, metronidazole, immunosuppressants, midazolam, triazolam, narcotic analgesics, rifabutin and rifabutin metabolite, sildenafil, warfarin, bupropion, clozapine, desipramine, piroxicam, quinidine, theophylline, and zolpidem. [Pg.1836]

Alprazolam, clonazepam, diazepam, midazolam, triazolam, Zolpidem Calcium channel blockers... [Pg.436]

CYP3A4 Midazolam, triazolam, cyclosporine, erythromycin, HIV protease inhibitors, calcium channel blockers Polymorphic... [Pg.35]

A similar phenomenon has been observed with the well-established mechanism-based inhibitor, diltiazem (108). Diltiazem (Cardizem SR , 120 mg b.i.d. for 7 days) caused a decrease in small bowel CYP3A activity of 62% with no corresponding change in intestinal CYP3A mRNA or protein expression. Many clinical studies have shown that diltiazem, a calcium channel blocker, inhibits the metabolism of CYP3A substrates, such as triazolam (109), midazolam (110), and... [Pg.533]

DILTIAZEM, VERAPAMIL BZDs Plasma concentrations of midazolam and triazolam are t by diltiazem and verapamil Diltiazem and verapamil inhibit CYP3A4-mediated metabolism of midazolam and triazolam 1 the dose of BZD by 50% in patients on calcium channel blockers warn patients not to perform skilled tasks such as driving for at least 10 hours after a dose of BZD... [Pg.90]

Single Phase I metabolic pathway CYP3A Alprazolam, midazolam, triazolam, verapamil, diltiazem, dihydro pyridine calcium channel blockers, lidocaine... [Pg.378]

Recent concerns with food products include grapefruit juice, which has been shown interact with many different medications through the CYP450 3A4 isoenzyme. This may increase the levels of medication such as cyclosporine, dihydropyridine calcium channel blockers, midazolam, triazolam, and astemizole. ... [Pg.1911]

Benzodiazepines alprazolam, clonazepam, diazepam, midazolam, triazolam, zolpidem Calcium channel blockers diltiazem, nifedipine, nimodipine, verapamil Steroids androgens, estrogens, cortisol Others erythromycin, terfenadine, cyclosporine, dapsone, ketoconazole, lovastatin, lidocaine, alfentanil, amiodarone, astemizole, codeine, sildenafil... [Pg.16]

CYP3A4 alprazolam, calcium channel blockers, cisapride, clarithromycin, cyclosporin A, erythromycin, HIV protease inhibitors, lidocaine, midazolam, simvastatin, terfenadine carbamazepine, dexamethsone, phenobarbital, phenytoin, rifampicin, St John s wort cimetidine, erythromycin, grapefruit juice, HIV protease inhibitors, itraconazole, ketoconazole... [Pg.510]

Modafinil is an inducer of the cytochrome P450 isoenzyme CYP3A4. The manufacturers therefore predict that it may reduce the levels of drugs that are CYP3A4 substrates. They specifically name the protease inhibitors, buspirone, calcium-channel blockers, ciclosporin, midazolam, and the statins [note that only some statins, namely atorvastatin, lovastatin and... [Pg.204]

Imatinib increases serum tacrolimus levels and is therefore predicted to increase ciclosporin levels. Imatinib may also increases the levels of some benzodiazepines (e.g. midazolam), some calcium-channel blockers (e.g. nifedipine), oestrogens, paracetamol, pimozide, and warfarin. In one case lansoprazole was suspected to have raised imatinib levels. [Pg.637]

Of the calcium-channel blockers diltiazem and verapamil are known to inhibit CYP3A4, the route by which benzodiazepines such as midazolam and triazolam are metabolised. Increased effects, such as sedation, which have been marked in some cases, have been seen in patients given these drugs. Alprazolam would be expected to interact similarly. There appear to be no clinically... [Pg.724]

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